450 ●^ PSYCHOTROPIC MEDICATIONS
Pregnancy Generic (Trade) Categories/NameHalf-life (hr) Indications
Therapeutic Plasma Level RangeAvailable Forms (mg)
●Lamotrigine*C/~33 Epilepsy●(Lamictal) Bipolar disorder
Not establishedTabs: 25, 100, 150, 200 Tabs (chewable): 2, 5, 25
●C/5–7 EpilepsyGabapentin* ● Postherpetic neuralgia(Neurontin; Gabarone)Unlabeled uses:● Bipolar disorder● Migraine prophylaxis● Neuropathic pain● Tremors associated with multiple sclerosis
Not establishedCaps: 100, 300, 400Tabs: 100, 300, 400, 600, 800 Oral Solution: 250/5 mL
●C/21 EpilepsyTopiramate*● Migraine prophylaxis(Topamax)Unlabeled uses:● Bipolar disorder● Cluster headaches● Bulimia● Weight loss in obesity
Not establishedTabs: 25, 50, 100, 200 Caps (sprinkle): 15, 25
●C/2 (metabolite 9) EpilepsyOxcarbazepine* (Trileptal)Unlabeled uses:● Alcohol withdrawal● Bipolar disorder● Diabetic neuropathy
Not establishedTabs: 150, 300, 600Oral Susp: 60/mL
* The FDA has issued a warning indicating reports of suicidal behavior or ideation associated with the use of these drugs (andother antiepileptic medica-
tions). The FDA now requires that all manufacturers of drugs in this class include a warning in their labeling to this effect.Results of a study published
2506_Ch27_447-471.indd 0450 2506 Ch 27 447 - 471 .indd 0450 in the December 2009 issue of Archives of General Psychiatry indicate that antiepileptic medications “do not increase risk of suicide attempts in patients 10/1/10 9:39:41 AM 10 with bipolar disorder” (Gibbons et al., 2009)./ 1 / 10 9 : 39 : 41 AM