GabapentinValproic acidClonazepamLamotrigineof:The effects Chlorpromazine, Valproic acidby:Are increased Cimetidine, CNS depressants, azole, metoprolol, propoxyphene, propranol, valproic felbamate, erythromycin, cimetidine, acid, probenecidcimetidine, hormonal contraceptives, morphine, naproxinhydrocodone, disulfi ram, fl uoxetine, isoniazid, ketocon-salicylates AntacidsPrimidone, Rifampin, by:Are decreased Rifampin, theophylline (cinimides, oral rifamycin, suc-effects),hydantoinsphenytoin, phenytoinphenobarbital, contraceptives, carbamazepine, cholestyramine, lamotrigine, phenobarbital, ethosuximide, ↓ sedative Mood-Stabilizing Drugs^ Concurrent use may result in:Increased effects ofIncreasedDecreased effects ofhydantoins, warfarin, zidovudine, hydantoinslevels; decreased effi cacy oftricyclic antidepres-sants, carbamazepine, CNS depressants, ethosuximide, lamotrigine, hydrocodonephenobarbital, levodopa phenytoin ●^453
TopiramateOxcarbazepineMet for min; hydrochlorothiazidePhenytoin, Carbamazepine, carbamazepine, valproic acid, acetaminophenphenobarbital, oxcarbazepine, verapamilvalproic acid, phenytoin, lamotriginecarbamazepine, Increased concentrations Increased risk of CNS Decreased levels ofdepression withphenytoin; alcohol oflamotriginedepressants.felodipine, risk of kidney stones withvalproic acid; carbonic anhydrase inhibitors. Increased levels of carbamazepine contraceptives, metformin, amitripty-line. effects ofof topiramatedigoxin, lithium, riseridone, valproic acid.effects of phenobarbital oral contraceptives, Decreased effects or otherphenytoin, oral Increased anddecreased andIncreased (^) CNS and^ and^
2 2506_Ch27_447-471.indd 0453 506 Ch 27 447 - 471 .indd 0453 1 10/1/10 9:39:42 AM 0 / 1 / 10 9 : 39 : 42 AM