VA L P RO I CBipolar Disorder, Mania:Restless Leg Syndrome:Migraine Prophylaxis:Neuralgias:Epilepsy LAMOTRIGINEManic Episodes:Epilepsy:Borderline Personality Disorder:Some patients may require up to 1000 mg/day. No evidence recommended dose: 60/mg/kg/day. therapeutic levels are reached. Maximum recommended 5 to 15 mg/kg/day. Increase by 5 to 10 mg/kg/week until or trough plasma levels of 50 to 125 mcg/mL. Maximum doses. Titrate to maintain a therapeutic plasma level of 50 to 100 mcg/mL. that higher doses lead to greater effiin divided doses. Titrate rapidly to desired clinical effect every 3 days until symptoms are controlled. may be increased in increments of 0.125 to 0.25 mg twice daily give in 2 divided doses. dosage: 60 mg/kg/day. When daily dosage exceeds 250 mg, patients may require up to 4 mg/day, in which case the dose ACID POAdults and children >12 years:^ PO(Lamictal) (^) : (Depakene; Depakote) Adults and children : 1.5 to 4 mg/day. PO (Stavzor only): Initial dose: 750 mg/day PO^ PO^ PO(Stavzor only): 250 mg twice daily. : 0.5 to 2 mg/night. : 1 to 6 mg/day. Mood-Stabilizing Drugs ≥PO: cacy. 10 years old: 750 mg/day in divided Adjunctive therapy Initial dose: ●^455
2506_Ch27_447-471.indd 0455 2506 Ch 27 447 - 471 .indd Bipolar Disorder: 0 Children 2For patients taking valproic acid: For patients taking carbamazepine or other enzyme-inducing drugs, 45 but not valproic acid: once daily for next 2 weeks; then increase by 25 to 50 mg/day every 1 to 2 weeks to maintenance dose of 50 to 200 mg twice a day. POwith carbamazepine, phenobarbital, phenytoin, or primidone:carbamazepine, valproic acid, or other enzyme-inducing drugs: PO:twice daily for next 2 weeks; then increase by 100 mg/day week 5: 100 mg/day; then 200 mg/day. on a weekly basis to maintenance dose of 300 to 500 mg/day in 2 doses. If valproic acid is also being taken, the initial dose should be 25 mg every other day for 2 weeks, then 25 mg other day; weeks 3 and 4: 25 mg/day; week 5: 50 mg/day; then 100 mg/day. mendations. 5 : 50 mg as a single daily dose for 2 weeks, then 50 mg Weeks 1 and 2: 25 mg/day; weeks 3 and 4: 50 mg/day;^ to^ 12 years:^ Escalation regimen:PO:Refer to manufacturer’s dosing recom- Weeks 1 and 2: 50 mg/day; weeks 3 PO: Weeks 1 and 2: 25 mg every^ For patients not taking^1 10/1/10 9:39:43 AM 0 / 1 / 10 9 : 39 : 43 AM
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