Mood-Stabilizing Drugs ●^465
Schizophrenia:Route and Dosage OLANZAPINEBipolar Disorder:Agitation Associated with Schizophrenia or Mania:May repeat in 2 hours and again 4 hours later, if needed. may increase every 24 hours by 5 mg/day (not to exceed 20 mg/day). at weekly intervals by 5 mg/day (not to exceed 20 mg/day). IM: 2.5 to 10 mg, administered slowly, deep into muscle mass.^ (Zyprexa) Adults:^ Adults: PO: 5 t o 10 m g /d a y i n it i a l l y ; m a y i nc r e a s e PO: 10 to 15 mg/day initially; Adults:
The effects of: Are increased by:ZiprasidoneAsenapine Fluvoxamine, imipra-Ketoconazole and mine, valproateother CYP-3A4 inhibitors CarbamazepineCarbamazepine, paroxetineAre decreased by:cimetidine, Increased effects of Concurrent use may result in: Life-threatening prolonga-trioxide, mefl oquine, dolasetron, tacrolimus, droperidol, gatifl oxacin, or moxifl oxacin. De-creased effects of levodopa and dopamine agonists. Increased CNS depression with alcohol or other CNS depressants. Increased hypotension with antihypertensives. tion of QT interval with quinidine, dofetilide, other class Ia and III antiarrhythmics, pimozide, sotalol, thioridazine, chlorpromazine, fl oquine, pentamidine, arsenic paroxetine and dextro-methorphan; Increased CNS depression with alcohol or other CNS depressants. Increased hypotension with antihy-pertensives; Additive effects on QT interval prolongation with quinidine, dofetilide, other Class Ia and III antiarrhythmics, pimo-
2506_Ch27_447-471.indd 0465 2506 Ch 27 447 - 471 .indd 0465 droperidol, gatifl oxacin, or moxifl oxacin.pentamadine, arsenic trioxide, mefl oquine, dolasetron, tacrolimus, chlorpromazine, fl oquine, zide, sotalol, thioridazine, 1 10/1/10 9:39:47 AM 0 / 1 / 10 9 : 39 : 47 AM