Contraindicated in:Contraindications and Precautions ● ● • Intestinal obstruction • Pregnancy or lactation (mias patients with long-QT syndrome or history of cardiac arrhyth-● administration with other drugs that prolong QT interval, or in lishedActiontory disease • Prostatic hypertrophy • CNS tumors • Epilepsy may exist among phenothiazines) • In comatose or severely cen-tral nervous system (CNS)-depressed clients • Poorly controlled seizure disorders • Clients with blood dyscrasias • Narrow angle glaucoma • Clients with liver, renal, or cardiac insuffi(increased risk of extrapyramidal reactions) • Diabetes • Respira-• Bone marrow depression • Concurrent with acute illnesses, infections, gastroenteritis, or dehydration Use Cautiously in:dopamine receptors in the basal ganglia, hypothalamus, limbic system, brainstem, and medulla.dopamine-mediated transmission of neural impulses at the Antipsychotic effects may also be related to inhibition of They also demonstrate varying affisynapses.These drugs are thought to work by blocking postsynaptic alpha) • Elderly patients with dementia-related psychosis (^1 -adrenergic, and histaminic receptors. • Elderly and debilitated patients • Children • Hypersensitivity (cross-sensitivity Antipsychotic Agents nity for cholinergic, pemozidesafety not estab- use • Co- ciency ●black^473
2 2506_Ch28_472-501.indd 1473 506 Ch 28 472 - 501 .indd ● ● box warning● ● ● ● ● ● ● 1 ● ● ● Adverse Reactions and Side Effects● ● ● ● ● 4 Sedation Weight g a i n Gynecomastia Retrograde ejaculation Amenorrhea Decreased libido Photosensitivity Orthostatic hypotension Agranulocytosis Reduction of seizure threshold Nausea Urinary retention Constipation Blurred vision Extrapyramidal symptoms 7 Dry mouth Skin rash 3 ) 10/1/10 9:40:04 AM 10 / 1 / 10 9 : 40 : 04 AM
