Nursing Diagnoses in Psychiatric Nursing Care Plans and Psychotropic Medications

ClozapineThe effects Loxapineof: Are increasedCaffeine, by:cimetidine, fl u v o x a m i n e , sertraline, fl u o x e t i n e , CYP3A4-inhibiting drugs (e.g., ritonavirrisperidone, citalopram, ketoconazole), CYP1A2 inducers Are decreased by:pine, omeprazole, nicotinephenobarbital, phenytoin, (e.g., carbamaze-rifampin), Antipsychotic Agents Additive CNS depression with result in:Concurrent use may Additive CNS depression with result in respiratory depres-arrest.with lorazepam (and possibly agents. Concomitant use effects with anticholinergic Additive anticholinergic with antihypertensive agents. sants. Increased hypotension alcohol or other CNS depres-coadministration.of risperidone with chronic sion, stupor, hypotension, and/or respiratory or cardiac arrest. Increased effects other benzodiazepines) may alcohol or other CNS depres-sants. Increased hypotension with antihypertensive agents. Additive anticholinergic effects with anticholinergic agents. Concomitant use with benzodiazepines may result in respiratory depres-sion, stupor, hypotension, and/or respiratory or cardiac ●^485

2506_Ch28_472-501.indd 1485 2506 Ch 28 472 - 501 .indd 1 InteractionsOlanzapineQuetiapine 485 Fluvoxamine, Cimetidine; itraconazole, fl u o x e t i n eerythromycin, or fl u c o n a z o l e , inhibitorsketoconazole, other CYP3A4 Carbamazepine, Phenytoin, omeprazole, thioridazinerifampin Decreased effects of levodopa Decreased effects of levodopa effects with anticholinergic Increased anticholinergic or other CNS depressants. CNS depression with alcohol antihypertensives. Increased Increased hypotension with and dopamine agonists. agents.Additive anticholinergic creased CNS depression with and dopamine agonists. In-with antihypertensives. effects with anticholinergic agents. sants. Increased hypotension alcohol or other CNS depres- 1 10/1/10 9:40:09 AM 0 / 1 / 10 9 : 40 : 09 AM