● ● ● ● ● • Patients with history of QT prolongation or cardiac arrhythmias • Concurrent use with drugs known to cause QT prolongationUse Cautiously in:● ment • Clients with history of seizures • Clients with diabe-tes or risk factors for diabetes • Clients exposed to temperature extremes • Elderly or debilitated clients • Clients with history of suicide attempt • Pregnancy and children (● lished● ● box warning● (e.g., dehydration [including from diuretic therapy or diarrhea], hypovolemia, concurrent antihypertensive therapy). Adverse Reactions and Side Effects● ●^488 ● Dry mouthExtrapyramidal symptoms Diarrhea Weight g a i nAnxiety Orthostatic hypotensionConstipation InsomniaHeadache Sedation DizzinessAgitationNausea^ ) • Elderly patients with dementia-related psychosis (●^ PSYCHOTROPIC MEDICATIONS) • Conditions that increase risk of hypotension • Clients with hepatic or renal impair-safety not estab-black
2 2506_Ch28_472-501.indd 1488 506 Ch 28 472 - 501 .ind● ● ● Interactions● ● ● ● ● ● ● ● ● ● d Prolonged QT intervalIncreased effects of analgesics Additive hypotension with Rash Additive orthostatic hypotension with coadministration of other drugs that result in this adverse reactionTa c h y c a r d i aAdditive anticholinergic effects with HyperglycemiaRhinitis alcohol, antihistamines, sedative/hypnotics, Increased effects of risperidone with paroxetine, Additive CNS depression with Decreased effects of Decreased effectiveness of risperidone with with risperidone, paliperidone, and ziprasidone 1488 or ritonavirclozapine levodopaantihypertensive agents and and CNS depressants, valproate other dopamine agonists anticholinergic agentsclozapine, flcarbamazepinewith risperidone or uoxetine, such as opioid 1 10/1/10 9:40:10 AM 0 / 1 / 10 9 : 40 : 10 AM
