Interactions● Adverse Reactions and Side Effects● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● Weight g a i nDisruption in the body’s ability to reduce core body Drowsiness, sedation, somnolenceIncreased salivationLightheadednessExtrapyramidal symptomswith HyperglycemiaInsomniaAdditive CNS effects with temperatureAnxiety, restlessnessConstipationDecreased plasma levels of aripiprazole with Nausea and vomitingand other Blurred visionHeadacheIncreased plasma levels and potential for aripiprazole toxicity with Decreased metabolism and increased effects of aripiprazole paroxetineAdditive hypotensive effects with CYP2D6 inhibitorsketoconazole CYP3A4 inducersor other CYP3A4 inhibitors, such as alcohol antihypertensive drugsand other quinidine, flAntipsychotic Agents CNS depressantscarbamazepine uoxetine, ●^ and^491
2506_Ch28_472-501.indd 1491 2506 Ch 28 472 - 501 .indd Route and Dosage Bipolar Mania:Children (13 to 17 years): Children (10 to 17 years): Schizophrenia: 149 required, additional dose increases may be made in 5 mg/day crease to 5 mg after 2 days and to 10 mg after 2 more days. If at lowest effective dose for symptom remission). increments. Maintenance dosage: 10 to 30 mg/day (maintain to achieve steady state. increases should not be made before 2 weeks, the time required a single dose. Doses up to 30 mg have been used. Dosage increase to 30 mg/day based on clinical response. Maximum dosage: 30 mg/day. crease to 5 mg after 2 days and to 10 mg after 2 more days. If required, additional dose increases may be made in 5 mg/day at lowest effective dose for symptom remission). increments. Maintenance dosage: 10 to 30 mg/day (maintain 1 Adults: Adults: PO: PO: PO:PO: Initial dose: 15 mg once daily. May Initial dose: 2 mg/day. May in-Initial dose: 2 mg/day. May in-Initial dose: 10 or 15 mg/day as 1 10/1/10 9:40:11 AM 0 / 1 / 10 9 : 40 : 11 AM
