Interactions^532 ● ● ● ● ● Bupropion● ● ● ● Atomoxetine● ● ● The effects Atomoxetineof:SeizuresSevere liver damageWeight g a i nNew or worsened psychiatric symptomsCoughWeight los sPalpitations; tachycardiaAbdominal painBlurred visionIncreased sweatingFatig ueTremor^ ●^ PSYCHOTROPIC MEDICATIONSby:Concomitant use of Are increased tors (paroxetine, fl uoxetine, CYP2D6 inhibi-quinidine) Are decreased by: Concurrent use may result in: Increased risk of cardiovascu-within 2 weeks of discontin-lar effects with oreffects of increased cardiovascular tially fatal reactions with concurrent use (or use uation) of vasopressors;MAO inhibitors;albuterolalbuterol poten- with
2 2506_Ch31_522-537.indd 1532 506 Ch 31 522 - 537 .inddBupropion 1532 Amantadine, guanfacine, triclopidine, cimetidine, levodopa, ritonavir Carbamazepine Increased risk of acute toxicity increased risk of seizures with drugs that lower the seizure threshold (antide-pressants, antipsychotics, theophylline, corticosteroids, stimulants/anorectics) increased risk of hyperten-(alcohol tolerance is reduced); increased antico-agulant effect of sion with concurrent useincreased effects of drugs metabolized by CYP2D6 (e.g., replacement agent; ramine, desipramine, paroxetine, fl uoxetine, sertraline, haloperidol, risperidone, thioridazine, metoprolol, propafe-none, adverse neuropsychiatric events with with nortriptyline, imip-MAO inhibitors;and nicotine fl e c a i n i d e )alcoholwarfarin;^ ;^1 10/1/10 9:40:58 AM 0 / 1 / 10 9 : 40 : 58 AM