P1: PSB Printer: Yet To Come
9780521704632ind CUFX213A/Peck 9780521618168 December 29, 2007 17:19
INDEX
Page numbers followed by “t” indicate tables and those followed by “f” indicate figures.αblockade
non-selective, 217 –219
see alsoα-adrenoceptor antagonists
α 1 blockade, selective, 219 –220
α 1 -agonists, 205
α 2 blockade, selective, 220
α 2 -agonists, 205
abciximab, 338
absorption of drugs,8–14
local anaesthetics, 167
pharmacokinetic interactions, 40 –41
acarbose, 350
accumulation of drug,76f
acebutolol,224t
acetate, 300
acetazolamide, 310
acetic acid derivatives, 156 –157
acetohexamide, 348 –349
acetyl group, 92
acetylation, 18 –19
acetylcholine (ACh), 175 –177
digoxin enhancement of release, 231
gastric secretion physiology, 292 –293
metabolism, 177
release, 175 , 197–199
structure,176f
synthesis, 175 , 176f
acetylcholine (ACh) receptor,2, 175–176
occupancy at neuromuscular junction,
38
subunits,3f
acetylcholinesterase (AChE), 175 , 177
acetyl-coenzyme A, 175
action potential, 163 , 164f, 229f
AChrelease, 175
cardiac, 228
activated partial thromboplastin time
(APTT), 342
active transport,3–4, 4f
blood–brain barrier, 15
acupuncture, 291
acyclovir, 333 –334adenosine, 233 –234
drug interactions, 233 –234
kinetics, 234
mechanism of action, 233
presentation, 233
side-effects, 233 –234
uses, 233
adenylyl cyclase, 28
ADP binding inhibition, 337 –338
adrenal medulla, 197 –199
adrenaline, 42 , 197–203
effects, 202
epidural anaesthetics, 14
kinetics, 203
mechanism of action, 202
metabolism, 18
nebulized, 13
presentation, 199 –201
uses, 199 –201
adrenergic neurone blockade, 263 –265
physiology, 263
α-adrenoceptor antagonists, 217 –220
actions,218t
combined,226t, 227t
non-selective, 217 –219
selective, 219 –220
β-adrenoceptor antagonists, 42 , 220, 226t,
235 –237
cardiac effects, 221 , 223t
circulatory effects,223t
combined,226t, 227t
intrinsic sympathomimetic activity,
220 –221, 221t
kinetics,223t, 224t
membrane stabilizing activity, 220 –221,
221t
metabolic effects,223t
pharmacological properties,222t
receptor selectivity, 220 –221, 221t
renin release effects, 259 –260
respiratory effects,223t
uses, 235