P1: PSB Printer: Yet To Come
9780521704632ind CUFX213A/Peck 9780521618168 December 29, 2007 17:19
370 Indexintravenous fluids, 298 , 304t
colloids, 300 , 304t
composition,302t
crystalloids, 300
intrinsic activity of drugs, 32 –33
iodides, 358
ion channel(s), 2
voltage-gated, 24 –25
ion channel receptors, ligand-gated,
25 –26
families, 25 –26
pentameric family, 25 –26
ion tapping, bupivacaine, 16
ionization,5–6
isobologram, 43 , 43f, 44
isocarboxazid, 277
isoflurane, 45 , 114, 121–122
effects, 121 –122
metabolism, 122
toxicity, 122
isomerism, 45
geometric, 46 –47
structural, 45
isomers
mixtures, 48
optical, 47 –48
racemic mixtures, 48
structural,46f
isoprenaline, 45 , 207–208
effects, 207 –208
kinetics, 208
presentation, 207
uses, 207
isoquinolones, 95
isosorbide dinitrate, 250 –251
isosorbide mononitrate, 250 –251
itraconazole, 332 –333juxtaglomerular apparatus, 258κreceptors, 137
kainate receptor, 26
ketamine, 37 , 102–103, 110t, 112t
effects,111t
enantiopure preparations, 49
kinetics,112t
presentation,110t, 111t
uses,110t, 111t
keto groups, 95
ketoconazole, 332 –333
keto-enol transformation, 45
ketorolac, 157
kidney
juxtaglomerular apparatus, 258
see alsorenal diseasekinetics, 156 , 256, 275, 287
non-linear, 78 –79
KOP (κreceptors), 137labetalol,226t, 227t
labour, distribution of drugs, 16 –17
β-lactam antibacterial drugs,
311 –318
β-lactam ring, 312 –313
β-lactamase, 312 –313, 317
lactate, 300
lamotrigine, 281
lansoprazole, 295
laudanosine, 95
lead-compounds, 85
levobupivacaine,171t
levofloxacin, 320 –321
Lewis acids, 122
ligands
natural, 25
receptor binding, 31 –32
lignocaine, 168 , 170t, 237–238
epidural route, 14
hepatocyte uptake rate, 11
intravenous regional anaesthesia,
168
kinetics, 168 , 170t, 238
mechanism of action, 237
preparations, 168
presentation, 237
side-effects, 237
uses, 237
ventricular arrhythmia treatment, 166 –168,
170t
lincosamides, 323 –324
linear functions, 51 , 51f
linezolid, 277
lipid sites, 99 –100
lipid solubility, 6
barbiturates,104t
general anaesthetic agents, 99 –100
local anaesthetics, 165
MAC relationship,100f
lipophilic areas, 99 –100
lisinopril, 260
lithium carbonate, 278 , 358
liver
active transport, 3
disease, 22
function tests, 22
NSAID toxicity, 152
loading dose, 75 –76
local anaesthetics, 163 , 174t
absorption, 167
cardiac effects, 166 –167