Pharmacology for Anaesthesia and Intensive Care

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Section IBasic principles

CH 2 —CH 2 —NH—CH—CH 2 —CH 2

—

CH3

HO

Dobutamine

OH

OH

N—

CH 3 O

(a) C 18 H 23 NO 3

Dihydrocodeine

HO

O

——

F

F

(b) C 3 H 2 CIF 5 O

Isoflurane Enflurane

H— C —O—C—C—F

——

Cl

H

——

F

F

——

F

F

H—C—O—C—C—F

—

—

F

F

——

Cl

H

CH 3

Figure 5.1.Structural isomers: (a) C 18 H 23 NO 3 ;(b) C 3 H 2 ClF 5 O.

Geometric


Optical

Geometric isomerism

This exists when a molecule has dissimilar groups attached to two atoms (often

carbon) linked either by a double bond or in a ring structure. The free rotation

of groups is restricted and so the groups may either be on the same side of the