186 Goulet^
eficial effect of EAABF was reported in an open
case study involving only 4 SBS patients with per-
sistent feeding intolerance [13]. A retrospective
study found a shorter duration of PN dependency
with the use of EAABF [14]. Current data are in-
sufficient to recommend such expensive formu-
las with often increased osmolality for infants
and children with SBS.
Glutamine (Gln) , a nonessential amino acid,
plays an important role in energy metabolism of
the intestinal mucosa and other rapid-turnover
tissues. A randomized controlled pilot study of
Gln-supplemented EF in infants with IF failed to
show any advantages [15]. Gln cannot be recom-
mende d u n le s s la rger mu lt ic enter t r ia l s on i n fa nt s
with IF provide evidence for beneficial effects.
Ta b l e 4. Different routes of feeding
Devices Indications Contraindications Advantages Disadvantages or risks
OF
None To be used
systematically
Artificial ventilation
Orofacial
malformation
Discontinuous physiologic
mode of feeding
Self-regulation of intake
EGF release by salivary
glands
Promotes bowel
adaptation
Psychological behavior
Insufficient intake
Gastric feeding
Nasogastric Nutritional support
<3 months
Severe GE reflux
Slow gastric emptying
Easy to place even at home Frequent dislodgements
Nasal symptoms
Percutaneous
endoscopic
gastrostomy
Nutritional support
>3 months
Repeated abdominal
surgery
Abnormal gastric
anatomy
Fewer occlusions with
larger bore, one-step low-
profile devices available
Skin injury at abdominal
exit site
Surgical
gastrostomy
Nutritional support
>3 months
Poor candidate for
surgery
Immediate placement of
low-profile device, direct
visualization of stomach
Open surgery
Duodenal or jejunal feeding
Nasojejunal Short term for
patients with severe
GERD, gastric
dysmotility
Recent proximal
surgical anastomosis
Radiologic or bedside
placement techniques
Noninvasive
Frequent dislodgements
Risk of intussusception
Nasal symptoms
Intestinal contamination
Gastrojejunal Longer-term EF for
patients with severe
GERD, gastric
dysmotility or need
for gastric
decompression
Recent proximal
surgical anastomosis
Endoscopic or radiologic
placement through
existing gastrostomy tube
Requires healing of
gastrostomy tract prior to
placement
Skin injury at abdominal
exit site
Frequent occlusions of
jejunal port
Intestinal contamination
Jejunal Long-term EF for
patients with severe
GERD and upper
intestinal dysmotility
Dysmotility Direct surgical access to
small intestine
Open surgical procedure
Mechanical problems
Intestinal contamination
GE = Gastroesophageal; GERD = gastroesophageal reflux disease.
Koletzko B, et al. (eds): Pediatric Nutrition in Practice. World Rev Nutr Diet. Basel, Karger, 2015, vol 113, pp 182–189
DOI: 10.1159/000360339