CHAPTER 3 Immune System^165
NURSING INTERVENTION
- Monitor vital signs, especially fever.
- Monitor fluid intake and output to assess for fluid overload and hydration status.
- Monitor coagulation factors.
Systemic Lupus Erythematosus (SLE)
WHAT WENT WRONG?
SLE is a chronic inflammatory immune disorder affecting the skin and other body
organs. Antibodies to DNA and RNA cause an autoimmune inflammatory response,
resulting in swelling and pain. It is most common in young women, and has a
strong genetic factor. The etiology is not known.
PROGNOSIS
Prognosis is good but is consistent with many remissions and exacerbations. Most
patients do quite well on a course of medications, but some progress rapidly with
severe organ involvement and subsequently, death. Certain medications may pro-
duce lupus-like symptoms in patients. A review of medications is indicated before
a diagnosis is made.
HALLMARK SIGNS AND SYMPTOMS
- Butterfly rash on face due to deposition of immunoglobulin and comple-
ment in the skin. - Fatigue may be due to anemia
- Anemia due to inflammation
- Fever, malaise
- Joint pain
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