BIOINORGANIC CHEMISTRY A Short Course Second Edition

CYTOCHROME bc 1 : A BACTERIAL CYTOCHROME 393

PDB No.(reference, date)

Species

(Crystal Space

Group, resolution, Å )

Inhibitor or Substrate (PDB abbreviation,

binding site)

heme c

— 1

[2Fe – 2S](Fe

and/or 1

Fe

) ( Å ) 2

[2Fe – 2S](Fe

and/or 1

Fe

) — heme 2 b

( Å ) L

heme b

—L

heme b

H

( Å )

[2Fe – 2S].

Position

a and

Mobility

b

1SQX( 88 , 2004)

bos Taurus(I4

22, 2.60) 1

inhibitor stigmatellin A(SMA, Q

) and substrate o

ubiquinone - 2 (UQ2, Q

) i

32.3 (Fe

) 2

30.8 (Fe

) 1

27.4 (Fe

) 2

26.1 (Fe

) 1

20.6

“ b ”

a

fi xed

b (SMA

induced)

1PP9( 90 , 2005)

bos Taurus(P2

(^2 1)
(^2 1)
, 2.10) 1
inhibitorStigmatellin (SMA, Q
) o
and substrate ubiquinone - 10 (UQ, Q
) i
32.0 (Fe
) 2
30.6 (Fe
) 1
27.2 (Fe
) 2
26.0 (Fe
) 1
20.6
“ b ”
a
fi xed
b (SMA
induced)
1NTK( 86 , 2004)
bos Taurus(I4
22, 2.60) 1
inhibitorantimycin A (AY1, Q
) i
32.8 (Fe
) 2
31.0 (Fe
) 1
26.8 (Fe
) 2
27.7 (Fe
) 1
20.6
“ b ”
a
3BCC( 84 , 1998)
Gallus gallus(P2
(^2 1)
(^2 1)
, 3.70) 1
InhibitorsStigmatellin (SIG, Q
) o
and antimycin A (AMY, Q
) i
31.6
26.4
“ b ”
a
1PPJ( 90 , 2005)
bos Taurus(P2
(^2 1)
(^2 1)
, 2.10) 1
InhibitorsStigmatellin (SMA, Q
) o
and antimycin A (ANY, Q
) i
32.0 (Fe
) 2
30.6 (Fe
) 1
27.2 (Fe
) 2
26.0 (Fe
) 1
20.6
“ b ”
a
a Position assessed by method of Iwata, et al., reference 83. b Mobility assessed by comparisons of anomalous Fe peak heights: data collected at or near the iron K absorption edge. (See r
eferences 84 and 88 .)