BIOINORGANIC CHEMISTRY A Short Course Second Edition

Figure 7.41 (A) Two B. taurus cytochrome c oxidase molecules, (PDB: 1V54, in green,
and PDB: 1V55 in cyan). Insert shows change in asp51 position. (B) The R. sparoides cyto-
chrome c oxidase molecule (PDB: 1M56). (Adapted with permission from Figure 1b of
reference 143. Copyright 2004, with permission from Elsevier.) Visualized using The
PyMOL Molecular Graphics System and ChemDraw Ultra, version 10.0. (Printed with
permission of Delano Scientifi c, LLC and CambridgeSoft Corporation.) (See color plate)

CuA

Mg H411

D407

R481

R482

E286

Y288 T359

K362

S197

S200 S201

Y33

N139

N121

N207

S299

S365

heme a CuB, heme a 3

D132

E101

subunit II

D-pathway

K-pathway

CuA

CuB

CuA

B

A

PDB: 1V54, green

PDB: 1V55, cyan

Bos taurus

H-bond network, black

asp51

heme a

heme a 3

lys265 begins

the K pathway

asp51

tyr440

PDB: 1M56

R. spharoides

D and K pathway

entrance aa residues

in green. H-bonding

network aa residues

in blue. Red dashed

lines describe proton

translocation routes.