Advices For Studying Organic Chemistry

cleavage at the C≡C.

RCCR'1.2.OHOAc^3 RCO 2 H + R'CO 2 H

RCCR'1. KMnO^4 ,OH

−

2. H+ RCO^2 H + R'CO^2 H

8.15 SYNTHETIC STRATEGIES REVISITED

1. Four interrelated aspects to be considered in planning a synthesis:
   
   
   1. Construction of the carbon skeleton.
   
   
   2. Functional group interconversion.
   
   
   
   

4)

2. Synthesis of 2-brom s or fewer:
   Retrosynthetic Analysis

3) Control of regiochemistry.

Control of stereochemistry.

obutane from compounds of two carbon atom

CH 3 CH 2 CHCH 3

Br

CH 3 CH 2 CH CH 2 + HBrMarkovnikov addition

Synthesis

CH 3 CH 2 CH CH 2 + HBrperoxideno CH 3 CH 2 CHCH

B

3

r

Target molecule Precursor

3. Synthesis of 1-butene from compounds of two carbon atoms or fewer:
   Retrosynthetic Analysis

CH 3 CH 2 CH CH 2 CH 3 CH 2 C

CH + H (^2)
CH 3 CH 2 CCH CH 3 CH 2 Br +NaC CH