Meister, A. (1991) Glutathione deficiency produced by
inhibition of its synthesis, and its reversal: applica-
tions in research and therapy. Pharmacology Therapy
51 , 155–194.
Meister, A. (1992a) Biosynthesis and functions of glu-
tathione, an essential biofactor. Journal of Nutrition
Science and Vitaminology (Tokyo), Special No., 1–6.
Meister, A. (1992b) On the antioxidant effects of ascor-
bic acid and glutathione. Biochemical Pharmacology
44 , 1905–1915.
Meister, A. (1995) Glutathione metabolism. Methods in
Enzymology 251 , 3–7.
Meydani, M., Evans, W.J., Handelman, G.et al.(1993)
Protective effect of vitamin E on exercise-induced
oxidative damage in young and older adults.
American Journal of Physiology 264 , R992–998.
Mills, P.C., Smith, N.C., Casas, I., Harris, P., Harris, R.C.
& Marlin, D.J. (1996) Effects of exercise intensity and
environmental stress on indices of oxidative stress
and iron homeostasis during exercise in the horse.
European Journal of Applied Physiology 74 , 60–66.
Moller, P., Wallin, H. & Knudsen, L.E. (1996) Oxidative
stress associated with exercise, psychological stress
and life-style factors. Chemical and Biological Interac-
tions 102 , 17–36.
Nadiger, H.A., Marcus, S.R., Chandrakala, M.V. &
Kulkarni, D.D. (1986) Malonyl dialdehyde levels in
different organs of rats subjected to acute alcohol tox-
icity. Indian Journal of Clinical Biochemistry 1 , 133–136.
Nadiger, H.A., Marcus, S.R. & Chandrakala, M.V.
(1988) Lipid peroxidation and ethanol toxicity in rat-
brain: effect of viatmin E deficiency and supplemen-
tation.Medical Science Research 16 , 1273–1274.
Nalbone, G., Leonardi, J., Termine, E.et al.(1989) Effects
of fish oil, corn oil and lard diets on lipid peroxida-
tion status and glutathione peroxidase activities in
rat heart. Lipids 24 , 179–186.
Novelli, G.P., Braccitiotti, G. & Falsini, S. (1990) Spin-
trappers and vitamin E prolong endurance to muscle
fatigue in mice. Free Radical Biology and Medicine 8 ,
9–13.
Novelli, G.P., Falsini, S. & Bracciotti, G. (1991) Exoge-
nous glutathione increases endurance to muscle
effort in mice. Pharmacological Research 23 , 149–156.
Ohno, H., Suzuki, K., Fujii, J.et al.(1994) Superoxide
dismutases in exercise and disease. In Exercise
and Oxygen Toxicity(ed. C.K. Sen, L. Packer &
O. Hanninen), pp. 127–161. Elsevier Science,
Amsterdam.
Packer, L. & Reznick, A.Z. (1992) Significance of
vitamin E for the athlete. In Vitamin E in Health and
Disease(ed. J. Fuchs & L. Packer), pp. 465–471. Marcel
Dekker, New York.
Packer, L., Gohil, K., deLumen, B. & Terblanche, S.E.
(1986) A comparative study on the effects of ascorbic
acid deficiency and supplementation on endurance
and mitochondrial oxidative capacities in various
tissues of the guinea pig. Comparative Biochemistry
and Physiology B 83 , 235–240.
Packer, L., Witt, E.H. & Tritschler, H.J. (1995) alpha-
Lipoic acid as a biological antioxidant. Free Radical
Biology and Medicine 19 , 227–250.
Packer, L., Roy, S. & Sen, C.K. (1997) Alpha-lipoic acid:
a metabolic antioxidant and potential redox modula-
tor of transcription. Advances in Pharmacology 38 ,
79–101.
Paffenbarger, R.S. Jr, Hyde, R.T., Wing, A.L. &
Steinmetz, C.H. (1984) A natural history of athleti-
cism and cardiovascular health. Journal of the Ameri-
can Medical Association 252 , 491–495.
Pincemail, J., Deby, C., Camus, G. et al.(1988)
Tocopherol mobilization during intensive exercise.
European Journal of Applied Physiology 57 , 189–191.
Poulsen, H.E., Loft, S. & Vistisen, K. (1996) Extreme
exercise and oxidative DNA modification. Journal of
Sports Science 14 , 343–346.
Powers, S.K. & Criswell, D. (1996) Adaptive strategies
of respiratory muscles in response to endurance
exercise. Medicine and Science in Sports and Exercise 28 ,
1115–1122.
Quintanilha, A.T. & Packer, L. (1983) Vitamin E, physi-
cal exercise and tissue oxidative damage. Ciba Foun-
dation Symposia 101 , 56–69.
Quintanilha, A.T., Packer, L., Davies, J.M., Racanelli,
T.L. & Davies, K.J. (1982) Membrane effects of
vitamin E deficiency: bioenergetic and surface
charge density studies of skeletal muscle and liver
mitochondria.Annals of the NY Academy of Science
393 , 32–47.
Rajguru, S.U., Yeargans, G.S. & Seidler, N.W. (1994)
Exercise causes oxidative damage to rat skeletal
muscle microsomes while increasing cellular
sulfhydryls.Life Sciences 54 , 149–157.
Reid, M.B., Stokic, D.S., Koch, S.M., Khawli, F.A. & Leis,
A.A. (1994) N-acetylcysteine inhibits muscle fatigue
in humans. Journal of Clinical Investigations 94 ,
2468–2474.
Reznick, A.Z., Witt, E., Matsumoto, M. & Packer, L.
(1992) Vitamin E inhibits protein oxidation in skele-
tal muscle of resting and exercised rats. Biochemical
and Biophysical Research Communications 189 , 801–
806.
Robinson, D.M., Ogilvie, R.W., Tullson, P.C. & Terjung,
R.L. (1994) Increased peak oxygen consumption of
trained muscle requires increased electron flux
capacity. Journal of Applied Physiology 77 , 1941–1952.
Rokitzki, L., Logemann, E., Huber, G., Keck, E. & Keul,
J. (1994a) alpha-Tocopherol supplementation in
racing cyclists during extreme endurance training
[see comments]. International Journal of Sport Nutri-
tion 4 , 253–264.
Rokitzki, L., Logemann, E., Sagredos, A.N., Murphy,
M., Wetzel-Roth, W. & Keul, J. (1994b) Lipid peroxi-
dation and antioxidative vitamins under extreme