(ICRP 26) and ED (ICRP 60). Some WTvalues are different and some are
the same in the two schema, whereas others are not given in the EDE
scheme. Because the radiosensitivity of tissues varies with age, the effective
dose is age dependent. Table 14.6 lists the effective doses in adult humans
from different nuclear medicine studies using various radiopharmaceuticals
(ICRP 80, 1999).
Pediatric Dosages
The metabolism, biodistribution, and excretion of drugs are different in
children from those in adults, and therefore radiopharmaceutical dosages
for children must be adjusted. Several methods and formulas have been
reported on pediatric dosage calculations based on body weight, body
222 14. Internal Radiation Dosimetry
Table14.6. Effective doses from various radiopharmaceuticals in nuclear medicine.
Effective dose*
Radiopharmaceuticals rem/mCi mSv/MBq
99mTc-pertechnetate 0.048 0.013
99mTc-sestamibi (exercise) 0.030 0.008
99mTc-MAA 0.004 0.001
99mTc-tetrofosmin (exercise) 0.026 0.007
99mTc-DTPA aerosol 0.022 0.006
99mTc-MDP 0.022 0.006
99mTc-red blood cell (RBC) 0.026 0.007
99mTc-imininodiacetic acid (IDA) derivatives 0.063 0.017
99mTc-DTPA 0.019 0.005
99mTc-dimercaptosuccinic acid (DMSA) 0.033 0.009
99mTc-sulfur colloid 0.033 0.009
99mTc-white blood cell (WBC) 0.004 0.001
99mTc-HMPAO 0.033 0.009
99mTc-ECD 0.041 0.011
99mTc-glucoheptonate 0.019 0.005
99mTc-MAG3 0.026 0.007
(^111) In-WBC 0.133 0.036
(^111) In-DTPA 0.078 0.021
(^111) In-pentetreotide 0.185 0.050
(^123) I-NaI (35% uptake) 0.814 0.220
(^131) I-NaI (35% uptake) 88.80 24.00
(^201) Tl-TlCl 0.814 0.22
(^18) F-FDG 0.070 0.019
(^67) Ga-citrate 0.370 0.100
(^131) I-MIBG 0.052 0.014
(^82) Rb-RbCl 0.013 0.003
- Adapted with permission from ICRP publication no. 80. New York: Pergamon Press; 1999.