Physics and Radiobiology of Nuclear Medicine

Effects of Radiation 233

A

Replication

Dicentric Fragment

Acentric Fragment

B

Fig. 15.7.(A)Illustration of restitution, in which the fragments produced by a
single-strand break in one arm of the chromosome by radiation join together to
produce the original chromosome. (B) Formation of dicentric and acentric
chromosomes by combination of the fragments, after replication from a single-
strand break in a chromosome.