Textbook of Personalized Medicine - Second Edition [2015]

100

Role of Molecular Diagnostics in Pharmacogenetics

Molecular diagnostic technologies used for pharmacogenetics have been described
in Chap. 2. Role of pharmacogenetic technologies in personalized medicine is
shown in Fig. 4.2.

Genetic Pharmacokinetics

polymorphism

Genotype Phenotype

Pharmacogenetics

Pharmacodynamics

Receptors

Ion Channels

Enzymes

Immune system

Absorption

Distribution

Metabolism

Excretion

© Jain PharmaBiotech

Fig. 4.1 Pharmacogenetics as a link between genotype and phenotype

PHARMACOGENETICS

POLYMORPHISMS IN

CANDIDATE GENES

IDENTIFICATION OF

PHARMACOLOGICAL TARGETS

SNP OR OTHER

POLYMORPHISM SCREENS

PRESCRIPTION OF

PERSONALIZED MEDICINE

IDENTIFICATION OF DISEASE

SUSCEPTIBILITY LOCI

DETERMINATION OF FUNCTIONAL

IMPORTANCE OF POLYMORPHISMS

MOLECULAR DIAGNOSTICS

© Jain PharmaBiotech

Fig. 4.2 Role of pharmacogenetic technologies in personalized medicine

4 Pharmacogenetics