xxvi
Personalized Management of Osteoporosis .............................................. 572
Personalized Management of Renal Disease ............................................ 573
Personalized Care of Trauma Patients ...................................................... 573
Personalized Medical Care of Astronauts During Space Flights .............. 574
References ................................................................................................. 57519 Personalized Non-pharmacological Therapies ..................................... 577
Introduction ............................................................................................... 577
Acupuncture .............................................................................................. 577
Personalized Acupuncture Therapy ...................................................... 578
Personalized Hyperbaric Oxygen Therapy ............................................... 578
Personalized Nutrition .............................................................................. 579
Nutrigenomics ....................................................................................... 580
Nutrition and Proteomics ...................................................................... 583
Personalized Diet Prescription .............................................................. 583
Personalized Physical Exercise ................................................................. 584
Variations in Response to Aerobic Exercise ......................................... 584
Variations in Exercise-Induced Muscle Hypertrophy
and Strength .......................................................................................... 585
Personalized Surgery................................................................................. 585
References ................................................................................................. 586
20 Development of Personalized Medicine ................................................ 589
Introduction ............................................................................................... 589
Players in the Development of Personalized Medicine ............................ 589
Personalized Medicine Coalition .......................................................... 590
Role of Pharmaceutical Industry ............................................................... 591
Personalized Drug Discovery ............................................................... 592
Personalized Approach to Clinical Trials .............................................. 592
Role of Drug Delivery in Personalized Medicine ................................. 595
Repositioning of Drugs for Personalized Medicine .............................. 595
Production and Distribution of Personalized Medicines ...................... 596
Role of Biotechnology Companies ........................................................... 597
Role of Life Sciences Industries ............................................................... 597
Role of the Clinical Laboratories .......................................................... 598
Role of Molecular Imaging in Personalized Medicine ......................... 598
Role of the US Government and Agencies in Personalized Medicine ...... 603
Department of Health and Human Services
and Personalized Medicine ................................................................... 604
Agency for Healthcare Research and Quality ....................................... 605
Comparative Effectiveness Research .................................................... 606
Role of the US Government Agencies in Personalized Medicine ........ 608
Role of Academic Institutions in the US ................................................... 614
Baylor College of Medicine .................................................................. 614
Coriell Personalized Medicine Collaborative™ ................................... 615
Delaware Valley Personalized Medicine Project .................................. 616
Duke University Medical Center and Genomic Medicine .................... 616
Contents