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which are responsible for the underlying disorder. The high number of rare, heteroge-
neous mutations present in all humans and the paucity of known functional variants
in >90 % of annotated genes make this challenge particularly diffi cult.
Role of neurogenomics in the development of personalized neurology is shown
schematically in Fig. 12.2 and various applications of neurogenomics are listed in
Table 12.1. Role of neurogenomics will be described in the following sections along
with the personalized management of various disorders. Many other factors besides
genomics are taken into consideration in tailoring the treatment to an individual patient.

Neurogenomics

Personalized

Neurology

Sequencing

Gene therapy

CNS disorders

Synthetic

biology

Biomarkers

Pharmacogenomics

CNS drug discovery

& development

Genetic

screening

Molecular

diagnosis

Molecular

neuropathology

© Jain PharmaBiotech

Fig. 12.2 Role of neurogenomics in the development of personalized neurology

Table 12.1 Applications of genomics in neurology

Basic neurosciences

Molecular neuropathology

Study of genes for neurologic disorders

Genomic studies of nonhuman organisms relevant to neurology

Creation of transgenic models of neurologic disorders

Brain mapping

Diagnosis of neurologic disorders

Redefi nition and reclassifi cation of disease

Molecular diagnostics

Biomarkers

Integration of diagnostics and therapeutics

Neurotherapeutics

Molecular neuropharmacology

Drug discovery and development

Gene therapy

Personalized neurology

© Jain PharmaBiotech

Neurogenomics