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Other principles of sepsis therapy and therapeutic adjuncts:
As previously discussed, successful management of sepsis includes early
initiation of supportive therapy, while at the same time addressing the source of
sepsis itself and minimizing secondary end-organ injury. In addition to the above
guidelines, the following measures should be implemented:
- Source control: Administer broad spectrum antibiotics early,[ 16 -
17 ] as part of the initial resuscitative efforts. The choice of
antibiotics will vary from one institution to another, based on the
local susceptibilities, microbiograms, and patient risk factors. For
instance, resistant organisms and fungus should be considered in
patients previously treated with antimicrobials. Therapy should not
be delayed while awaiting collection of cultures. Antimicrobials
should be administered within the hour once sepsis is suspected.
Typical empiric therapy may include drugs, such as Ampicillin and
Cefotaxime in infants and Vancomycin and Cefotaxime in children
who are previously healthy. Zosyn and Vancomycin are also a