fall in this category.
b. Medium size molecules. 500-5000 Daltons
c. Large molecules. 5000-50000 Daltons. Include proteins and cytokines
6. Sieving coefficient.
Is the ability of a molecule to pass through the membrane. A Sieving
coefficient of 1 indicates that 100% of the solute will move across the
membrane (K, Na, Creatinine, etc). Proteins have a Sieving coefficient of
zero as they are unable to pass across the membrane due to their large
size.Continuous vs. intermittent renal replacement therapy [5]
Continuous renal replacement therapy, has the advantage of providing
clearance of nitrogenous waste products, correction of
electrolytes/acid-base abnormalities and management of fluid overload
with a much gentler and effective mechanisms than intermittent
hemodialysis.
Due to the small blood volumes in small children, intermittent HD is
difficult. The frequent episodes of hypotension could compromise even
more the perfusion of end organs in the critically ill child.
When used, the utilization of volume-controlled dialysis machines is
extremely important in children. Frequent hematocrit measurements
during dialysis help prevent sudden changes in intravascular volume
Continuous RRT uses convection or hemofiltration by which, water and
solutes are eliminated without causing volume shifts or hypotension.
Hemofiltration is the preferred method of RRT in critically ill and small
children due to their small blood volumes.