ECMO-/ECLS

 Onset & elimination: 10-15 minute onset. Elimination 20- 45

hours.

 Precautions:

o Associated with tolerance and withdrawal.

o Can cause hypotension – infuse slowly over 15- 30

minutes.

o Mixed in propylene glycol – avoid continuous infusion

that may cause metabolic acidosis and nephrotoxicity

C. Chloral hydrate [2]
Sedative. Mechanism unknown, however likely causes global neuronal
depression, without side effects of respiratory depression, emesis, or
hemodynamic alterations.
 Dosing: 25-50mg/kg for sedation PO or PR. 50-100mg/kg for
hypnotic doses for procedures
 Onset of action: 30 minutes, duration 2-4 hours. half life 4- 6
hours
 Precautions: risk of laryngeal edema, cardiac arrhythmias,
pneumatosis intestinalis

D. Ketamine [2]^