ECMO-/ECLS

(^) Pharmacological Closure of PDA Dosage Guidelines
Drug Treatment dose Prophylactic dose Route of Administratio
n
PDA Closure
Rate
AEffectsdverse Reopeni
ng rate
Indomethacin Age < 48 hours:
(^1) 0.2mg/kgst dose:
(^2) 0.1nd dose:mg/kg
after 12 hours
(^3) 0.1mg/kg 24 rd dose:
hours after 2dose nd
(^) Age > 48
hours:0.2mg/kg/dos
e at 12hour intervals - 24
for total of 3 doses
(^1) (<24 hours st dose
age, preferably
<12 hours age): 0.1-
0.2 mg/kg
Subsequent 2 doses:
0.1mg/kg every 24
hours
IV over 30 minutes 70 80%- Renal function+:
oliguria, rising
creatinineGI:
bleding, perforatio
n, NEC, electrolyte
disturbance
20 - 30%
Ibuprofen Loading dose: 10mg/kg
(^) Subsequent
doses:5mg/kg for 2
doses at 24 hour intervals
(^1) 10mg/kg IV st dose:
or oral at < 6 hours age
(^) Subsequent
2 doses: 5mg/kg at
24 and 48 hours age
IV or Oral (^70) 80%- Oliguria, rising
creatinineHigher
serum bilirubin
Bleedingless -
common
30%
Paracetamol Oral dosing: 15 mg/kg every 6
hoursDuration: 48 (^) -
72 hours for 3 doses
OralIV* Needs Further
Study
Elevated liver
enzymes