Science - USA (2022-01-07)

4 7 JANUARY 2022 • VOL 375 ISSUE 6576 science.org SCIENCE

ILLUSTRATION: NICOLLE FULLER AT SAYO STUDIO

RESEARCH

IN BRIEF

36 From Science and other journals

REVIEW

39 Cancer
Tertiary lymphoid structures in cancer
T. N. Schumacher and D. S. Thommen
REVIEW SUMMARY; FOR FULL TEXT:
DOI.ORG/10.1126/SCIENCE.ABF

RESEARCH ARTICLES

40 Organoids
Tissue geometry drives
deterministic organoid patterning
N. Gjorevski et al.
RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:
DOI.ORG/10.1126/SCIENCE.AAW
PERSPECTIVE p. 26

41 Neuroscience
Dense functional and molecular readout
of a circuit hub in sensory cortex
C. Condylis et al.
RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:
DOI.ORG/10.1126/SCIENCE.ABL

42 Neuroscience
A neuronal mechanism for
motivational control of behavior
J. Courtin et al.
RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:
DOI.ORG/10.1126/SCIENCE.ABG

43 Coronavirus
Immune correlates analysis of the
mRNA-1273 COVID-19 vaccine efficacy
clinical trial P. B. Gilbert et al.
PERSPECTIVE p. 22

50 Spliceosome
Structural basis of branch site recognition
by the human spliceosome
J. Tholen et al.

REPORTS

57 Geophysics

On the relative temperatures of Earth’s

volcanic hotspots and mid-ocean ridges

X. Bao et al.

62 Nanomaterials

Single-walled zeolitic nanotubes

A. Korde et al.

PERSPECTIVE p. 29

66 Batteries

Capturing the swelling of solid-electrolyte

interphase in lithium metal batteries

Z. Zhang et al.

71 Solar cells

Metastable Dion-Jacobson 2D structure

enables efficient and stable perovskite

solar cells F. Zhang et al.

76 Heavy fermions

Evidence for a delocalization quantum phase

transition without symmetry breaking in

CeCoIn N. Maksimovic et al.

82 Neuroscience

Voltage compartmentalization in dendritic

spines in vivo V. H. Cornejo et al.

86 Structural biology

Cryo-EM structure of human GPR

receptor coupled to the RGS7-Gb5 signaling

complex D. N. Patil et al.

91 Cell and gene therapy

CAR T cells produced in vivo to treat

cardiac injury J. G. Rurik et al.

PERSPECTIVE p. 23

97 Nitrogen cycle

Oxygen and nitrogen production by an

ammonia-oxidizing archaeon B. Kraft et al.

PERSPECTIVE p. 27

101 Paleoecology

Smaller fish species in a warm and

oxygen-poor Humboldt Current system

R. Salvatteci et al.

PERSPECTIVE p. 25

104 Structural virology

Structural basis of synergistic neutralization

of Crimean-Congo hemorrhagic fever virus

by human antibodies

A. K. Mishra et al.

ON THE COVER

Lipid nanoparticles (spheres) use antibodies

against the CD5 protein (antibodies, blue;

CD5, red) to specifically target T cells

while inside the bloodstream and tissues.

The nanoparticles deliver mRNA to T cells,

reprogramming them in vivo to transiently

express chimeric antigen receptors (gold)

that target pathogenic

cardiac fibroblasts.

In vivo–engineered

T cells mitigate cardiac

fibrosis and improve

heart function in a

mouse model. See pages

23 and 91. Illustration:

C. Bickel/Science

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CONTENTS

DEPARTMENTS

5 Editorial

Looking ahead, looking back

By H. Holden Thorp

114 Working Life

Beyond Title IX

By Savannah A. Collins-Key

New Products ..............................................

Science Careers .......................................... 111

BOOKS E T A L.

34 Deciphering Egypt’s Great Pyramid
An ancient archive offers new insights
into the construction of a man-made
wonder By A. Robinson

35 Confronting age-old questions,
big and small
A wry romp through science’s greatest hits
and challenges entertains and illuminates
By M. Engel
41

Diverse neuronal types form functional circuits in the rodent primary somatosensory cortex