The Essentials of Biostatistics for Physicians, Nurses, and Clinicians

144 CHAPTER 8 Contingency Tables

paired sulphoxidation (SI ≤ 6.0). The results are given in the 2 × 2 table

below (Table 8.19 ).

(a) Using Fisher ’ s exact test, determine whether or not impaired sulphoxi-

dation affects toxicity.

(b) Perform a chi - square test on the 2 × 2 table.

(c) Are the results of the tests similar?

Table 8.19

Relationship Between High or Normal

Sulphoxidation Index and Major Toxicity

Reaction

Major adverse reaction (toxicity)

Yes No Total

Impaired sulphoxidation (SI > 6.0) Yes 32 9 41

No 12 22 34

Total 44 31 75

Table 8.18

Fasting Blood Glucose Levels (normal vs. out of

normal range) vs. Drug Treatment Group

Fbg level at

follow - up

Patients with

investigational drug

Patients with

approved drug

Total

Normal 119 21 140

Not normal 81 179 260

Total 200 200 400