Comparative and Veterinary Pharmacology

Table 9

Susceptibility of swine respiratory disease pathogens to antimicrobial agents

Organism

MIC

90

*(

mg/mL)

Ceftiofur Amoxicillin/

clavulanic acid (2/1)

Tiamulin Tulathromycin Oxytetracycline Florfenicol Trimethoprim/

sulfamethoxazole(1/19)

Enrofloxacin

Pasteurella multocida



0.004 0.32/0.16

32

1

1

0.5

0.12/2.4



0.016–0.125

Actinobacillus

pleuropneumoniae



0.008 0.32/0.16

8

16



16

0.5

8/152

0.06

Mycoplasma

hyopneumoniae

• 
  


• 
  

0.05

0.06

2

0.5

• 
  

0.01

Bordetella

bronchiseptica

16

4/2



32

4



16

4–8

4/76

0.5

*Minimum drug concentration required for the inhibition of 90% of isolatesSources

: Aarestrup et al. (2004); Godinho (2008); Godinho et al. (2005a); Hannan et al. (1997); Jones et al. (2002); Kadlec et al. (2004); Kehrenberg et al.

(2004); Priebe and Schwarz (2003); Rosenbusch et al. (2005); Salmon et al. (1996); Schwarz et al. (2004); Vicca et al. (2004)Table 10

Pharmacokinetics of antimicrobial agents used parenterally for the treatment of swine respiratory disease

Dose (mg/kg) Route

Cmax

(m

g/mL)

Tmax

(h) AUC (

mg h/mL) Terminal T1/2 (h) F (%) References

Ceftiofur*

3

IM

15.8

0.5 – 4

196

14.3

NR

Brown et al. (1999)

Tulathromycin

2.5

IM

0.62

0.25

15.2

75.6

87.7

Benchaoui et al. (2004)

Florfenicol

20

IM

3.5

1

84.3

17.2

96.9

Jiang et al. (2006)

Enrofloxacin** 2.5

IM

1.17

1.81

12.1

NR

Anado

́n et al. (1999)

Oxytetracycline 30

IM

15.4

1.7

399

68.5

NR

El Korchi et al. (2001)

*As ceftiofur sodium**

Parameters reported for the parent compound

NR: not reported

Population Medicine and Control of Epidemics 131