Table 3Predicted and observed clearance (mL/min) in large animals with and without inclusion
of a large animal based on simple allometrya
Species used Exponents R Species predicted Observed Cl Predicted Cl Error
Caffeine
Dog, human, donkey 0.727 0.998 Horse 312 340 0.92
Camel 292 82 3.56
Dog, human, horse 0.762 0.999 Donkey 221 256 1.16
Camel 82 323 3.94
Antipyrine
Dog, human, camel 0.827 0.765 Horse 2,790 860 0.31
Dog, human, horse 0.951 0.795 Camel 1,613 1,038 0.64
Theophylline
Dog, goat, horse 0.688 0.793 Camel 2,288 478 0.21
Dog, goat, camel 1.261 0.957 Horse 387 3,657 9.45
Enrofloxacin
Dog, sheep, cow 0.784 0.897 Mare 3,331 3,552 1.07
Camel 2,088 3,095 1.47
Dog, sheep, mare 0.676 0.969 Cow 5,775 3,063 0.53
Camel 2,088 2,261 1.08
Dog, mare, camel 0.554 0.987 Cow 2,088 3,230 1.55
Sheep 209 703 3.36
Cefoperazone
Dog, human, horse 1.189 0.875 Calf 653 348 0.53
Sheep 107 153 1.43
Dog, human, calf 0.703 0.504 Horse 4,981 758 0.15
Sheep 107 146 1.36
Furosemide
Dog, human, horse 1.149 0.934 Camel 1,334 1,740 1.3
Dog, human, camel 0.864 0.923 Horse 4,981 1,632 0.33
Sulphadimidine
Dog, goat, horse 1.248 0.99 Cattle 498 737 1.48
Camel 136 186 1.37
Sheep 19 14 0.74
Dog, goat, cattle 1.161 0.993 Horse 253 217 0.86
Camel 136 150 1.1
Sheep 19 13 0.68
Dog, goat, camel 1.175 0.988 Cattle 498 555 1.11
Horse 253 220 0.87
Sheep 19 13 0.68
Flunixin
Sheep, calf, donkey 1.69 0.92 Horse 492 1,868 3.8
Mule 654 2,012 3.08
Camel 705 2,070 2.94
Sheep, mule, donkey 1.386 0.987 Horse 492 754 1.53
Calf 397 120 0.3
Camel 705 820 1.16
Dog, sheep, donkey 1.173 0.973 Horse 492 707 1.44
Calf 397 150 0.38
Camel 29 759 1.08
Mule 654 744 1.14
Dog, sheep, camel 1.109 0.986 Horse 492 565 1.15
Calf 397 130 0.33
Sheep 29 44 1.52
Mule 654 593 0.91
aData modified from Mahmood et al. ( 2006 )
150 R.P. Hunter