Brophy B, Smolenski G, Wheeler T, Wells D, L’Huillier P, Laible G (2003) Cloned transgenic
cattle produce milk with higher levels of beta-casein and kappa-casein. Nat Biotechnol
21:157–162
Brown PA, Bodles-Brakhop AM, Pope MA, Draghia-Akli R (2009) Gene therapy by electropora-
tion for the treatment of chronic renal failure in companion animals. BMC Biotechnol 16:4
Campbell KH, McWhir J, Ritchie WA, Wilmut I (1996) Sheep cloned by nuclear transfer from a
cultured cell line. Nature 380:64–66
Chowdhary BP, Raudsepp T (2008) The horse genome derby: Racing from map to whole genome
sequence. Chromosome Res 16:109–127
Chowdhary BP, Paria N, Raudsepp T (2008) Potential applications of equine genomics in
dissecting diseases and fertility. Anim Reprod Sci 107:208–218
Cooper BJ, Winand NJ, Stedman H, Valentine BA, Hoffman EP, Kunkel LM, Scott MO,
Fischbeck KH, Kornegay JN, Avery RJ et al (1988) The homologue of the Duchenne locus
is defective in X-linked muscular dystrophy of dogs. Nature 334:154–156
Cutrera J, Torrero M, Shiomitsu K, Mauldin N, Li S (2008) Intratumoral bleomycin and IL-12
electrochemogenetherapy for treating head and neck tumors in dogs. Methods Mol Biol
423:319–325
Davidson DJ, Dorin JR, McLachlan G, Ranaldi V, Lamb D, Doherty C, Govan J, Porteous DJ
(1995) Lung disease in the cystic fibrosis mouse exposed to bacterial pathogens. Nat Genet
9:351–357
Dow SW, Elmslie RE, Willson AP, Roche L, Gorman C, Potter TA (1998) In vivo tumor
transfection with superantigen plus cytokine genes induces tumor regression and prolongs
survival in dogs with malignant melanoma. J Clin Invest 101:2406–2414
Dow S, Elmslie R, Kurzman I, MacEwen G, Pericle F, Liggitt D (2005) Phase I study of liposome-
DNA complexes encoding the interleukin-2 gene in dogs with osteosarcoma lung metastases.
Hum Gene Ther 16:937–946
Edwards JL, Schrick FN, McCracken MD, van Amstel SR, Hopkins FM, Welborn MG, Davies CJ
(2003) Cloning adult farm animals: a review of the possibilities and problems associated with
somatic cell nuclear transfer. Am J Reprod Immunol 50:113–123
Erickson JC, Clegg KE, Palmiter RD (1996) Sensitivity to leptin and susceptibility to seizures of
mice lacking neuropeptide Y. Nature 381:415–421
Farid SS (2007) Process economics of industrial monoclonal antibody manufacture. J Chromatogr
B Anal Technol Biomed Life Sci 848:8–18
Finocchiaro LM, Glikin GC (2008) Cytokine-enhanced vaccine and suicide gene therapy as
surgery adjuvant treatments for spontaneous canine melanoma. Gene Ther 15:267–276
Galli C, Lagutina I, Crotti G, Colleoni S, Turini P, Ponderato N, Duchi R, Lazzari G (2003)
Pregnancy: A cloned horse born to its dam twin. Nature 424:635
Gardier AM, Guiard BP, Guilloux JP, Repe ́rant C, Coudore ́F, David DJ (2009) Interest of using
genetically manipulated mice as models of depression to evaluate antidepressant drugs activ-
ity: a review. Fundam Clin Pharmacol 23:23–42
Garrick D, Fiering S, Martin DI, Whitelaw E (1998) Repeat-induced gene silencing in mammals.
Nat Genet 18:56–59
Gordon JW, Scangos GA, Plotkin DJ, Barbosa JA, Ruddle FH (1980) Genetic transformation of
mouse embryos by microinjection of purified DNA. Proc Natl Acad Sci USA 77:7380–7384
Grubb BR, Boucher RC (1999) Pathophysiology of gene-targeted mouse models for cystic
fibrosis. Physiol Rev 79:S193–214
Hammer RE, Pursel VG, Rexroad CE Jr, Wall RJ, Bolt DJ, Ebert KM, Palmiter RD, Brinster RL
(1985) Production of transgenic rabbits, sheep and pigs by microinjection. Nature 315:680–683
Hao Y, Wax D, Zhong Z, Murphy C, Ross JW, Rieke A, Samuel M, Spate L, Dyce P, Li J,
Sutovsky P, Prather RS (2009) Porcine skin-derived stem cells can serve as donor cells for
nuclear transfer. Cloning Stem Cells 11:101–110
Houdebine LM (2009) Production of pharmaceutical proteins by transgenic animals. Comp
Immunol Microbiol Infect Dis 32:107–121
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