Jensen VF, Neimann J, Hammerum AM, Molbak K, Wegener HC (2004) Does the use of anti-
biotics in food animals pose a risk to human health? An unbiased review? J Antimicrob
Chemother 54:274–275
Kaspar H (2006) Results of the antimicrobial agent susceptibility study raised in a representative,
cross-sectional monitoring study on a national basis. Int J Med Microbiol 296(Suppl 41):69–79
Kaufmann GF, Park J, Janda KM (2008) Bacterial quorum sensing: A new target for anti-infective
immunotherapy. Exp Opin Biol Ther 8:719–724
Keren I, Shah D, Spoering A, Kaldalu N, Lewis K (2004) Specialized persister cells and the
mechanism of multidrug tolerance inEscherichia coli. J Bacteriol 186:8172–8180
Kong KF, Vuong C, Otto M (2006) Staphylococcus quorum sensing in biofilm formation and
infection. Int J Med Microbiol 296:133–139
Ko ̈rber B, Luhmer E, Wetzstein HG, Heisig P (2002) Abstracts 42nd ICAAC. San Diego, USA,
Abstract F-567, p188
Labro MT (1998) Anti-inflammatory activity of macrolides: a new therapeutic potential?
J Antimicrob Chemother 41(Suppl B):37–46
Lavda M, Clausnitzer CE, Walters JD (2004) Distribution of systemic ciprofloxacin and doxycy-
cline to gingiva and gingival crevicular fluid. J Periodontol 75:1663–1667
Lees P, Aliabadi FS, Toutain PL (2006) Minimising antimicrobial resistance through rational
design of dosing schedules: A role for pre-clinical PK-PD modeling. J Vet Pharmacol Ther 29
(Suppl 1):24–26
Leslie G (2008) Surveying therapets for MRSA. Vet Rec 162:388
Lewis K (2007) Persister cells, dormancy and infectious disease. Nat Rev Microbiol 5:48–56
Lewis K (2008) Multidrug tolerance of biofilms and persister cells. Curr Top Microbiol Immunol
322:107–131
Liautard JP, Jubier-Maurin V, Boigegrain RA, Ko ̈hler S (2006) Antimicrobials: Targeting viru-
lence genes necessary for intracellular multiplication. Trends Microbiol 14:109–113
Liu P, Mu ̈ller M, Grant M, Webb AI, Obermann B, Derendorf H (2002) Interstitial tissue
concentrations of cefpodoxime. J Antimicrob Chemother 50(Suppl 1):19–22
Long KS, Poehlsgaard J, Kehrenberg C, Schwarz S, Vester B (2006) The Cfr rRNA methyltrans-
ferase confers resistance to phenicols lincosamides oxazolidinones pleuromutilins and strepto-
gramin A antibiotics. Antimicrob Agents Chemother 7:2500–2505
Lynch SV, Wiener-Kronish JP (2008) Novel strategies to combat bacterial virulence. Curr Opin
Crit Care 14:593–599
MacGowan A, Bowker K (2002) Development in PK/PD: Optimizing efficacy and prevention
of resistance. A critical review of PK/PD in in vitro models. Int J Antimicrob Agents 19:
291–298
Maldonado EN, Romero JR, Ochoa B, Aveldan ̃o MI (2001) Lipid and fatty acid composition of
canine lipoproteins. Comp Biochem Physiol B Biochem Mol Biol 128:719–729
Maldonado EN, Casanave EB, Aveldan ̃o MI (2002) Major plasma lipids and fatty acids in four
HDL mammals. Comp Biochem Physiol A Mol Integr Physiol 132:297–303
Malik M, Hussain S, Drlica K (2007) Effect of anaerobic growth on quinolone lethality with
Escherichia coli. Antimicrob Agents Chemother 51:28–34
Marriott HM, Mitchell TJ, Dockrell DH (2008) Pneumolysin: A double-edged sword during the
host-pathogen interaction. Curr Mol Med 8:497–509
Martinez M, Modric S (2010) J Vet Pharmacol Ther (Submitted)
Martinez M, Toutain PL, Walker RD (2006) The pharmacokinetic-pharmacodynamic (PK/PD)
relationship of antimicrobial agents. In: Gigue`re S, Prescott JF, Baggot JS, Walker RD,
Dowling PM (eds) Antimicrobial therapy in veterinary medicine, 4th edn. Blackwell, Oxford,
pp 81–106
Masterton R (2008) The importance and future of antimicrobial surveillance studies. Clin Infect
Dis 47(Suppl 1):S21–S31
McEwen SA, Fedorka-Cray PJ (2002) Antimicrobial use and resistance in animals. Clin Infect Dis
34(Suppl 3):S93–S106
Antimicrobial Drug Resistance 261