Veterinary Medicines and Competition
Animals: The Question of Medication
Versus Doping Control
Pierre-Louis Toutain
Contents
1 Introduction ............................................................................. 317
2 Rationale for Anti-doping Versus Medication Control ................................. 317
3 Medication Versus Doping Control: Progress Towards a General Policy
Giving Priority to the Welfare and Safety of the Horse ................................. 318
3.1 Doping Agents and Doping Control Issues ........................................ 319
3.2 Medication Issues and Medication Control ........................................ 322
4 Analytical Method and Doping Testing ................................................. 323
5 Blood Versus Urine Testing and the Rationale for Selecting a Matrix for Doping
and Medication Control ................................................................. 324
6 Substances Requiring a Threshold ...................................................... 326
7 Testing Exposure and the End of a Zero Tolerance Approach for Medication Control ... 327
8 The Decision Making Process on No Significant Effect Levels: A Risk
Analysis Integrated Approach .......................................................... 330
8.1 Risk Assessment ................................................................... 330
8.2 Risk Management .................................................................. 333
8.3 Risk Communication: Detection Times Versus Withdrawal Times ............... 334
9 From a Detection Time to a Withdrawal Time ......................................... 335
10 Conclusion .............................................................................. 336
References .................................................................................... 337
AbstractIn racing and other equine sports, it is possible to increase artificially
both the physical capability and the presence of a competitive instinct, using drugs,
such as anabolic steroids and agents stimulating the central nervous system. The
word doping describes this illegitimate use of drugs and the primary motivation of
an equine anti-doping policy is to prevent the use of these substances. However, an
anti-doping policy must not impede the use of legitimate veterinary medications
P.‐L. Toutain
UMR181 Physiopathologie et Toxicologuie Experimentales INRA, ENVT, Ecole Nationale
Ve ́te ́rinaire de Toulouse – 23 chemin des Capelles – 31076, Toulouse cedex 03, France
e-mail: [email protected]
F. Cunningham et al. (eds.),Comparative and Veterinary Pharmacology,
Handbook of Experimental Pharmacology 199,
DOI 10.1007/978-3-642-10324-7_13,#Springer-Verlag Berlin Heidelberg 2010
315