receptors of the most TCDD-susceptible and the most TCDD-resistant rat strains. Toxicol Appl
Pharmacol 155:82–95
Poland A, Glover E (1990) Characterization and strain distribution pattern of the murine Ah
receptor specified by theAhdandAhb-3alleles. Mol Pharmacol 38:306–312
Poland A, Palen D, Glover E (1994) Analysis of the four alleles of the murine aryl hydrocarbon
receptor. Mol Pharmacol 46:915–921
Pulliam JD, Seward RL, Henry RT, Steinberg SA (1985) Investigating ivermectin toxicity in
collies. Vet Med 80:33–40
Rempel WE, Lu M, el Kandelgy S, Kennedy CF, Irvin LR, Mickelson JR, Louis CF (1993)
Relative accuracy of the halothane challenge test and a molecular genetic test in detecting the
gene for porcine stress syndrome. J Anim Sci 71:1395–1399
Richter RJ, Jarvik GP, Furlong CE (2009) Paraoxonase 1 (PON1) status and substrate hydrolysis.
Toxicol Appl Pharmacol 235:1–9
Riedesel DH, Hildebrand SV (1985) Unusual response following use of succinylcholine in a horse
anesthetized with halothane. J Am Vet Med Assoc 187:507–508
Ritter MJ, Ellis M, Hollis GR, McKeith FK, Orellana DG, Van Genugten P, Curtis SE, Schlipf JM
(2008) Frequency of the HAL-1843 mutation of the ryanodine receptor gene in dead and
nonambulatory-noninjured pigs on arrival at the packing plant. J Anim Sci 86:511–514
Roberts MC, Mickelson JR, Patterson EE, Nelson TE, Armstrong PJ, Brunson DB, Hogan K (2001)
Autosomal dominant canine malignant hyperthermia is caused by a mutation in the gene
encoding the skeletal muscle calcium release channel (RYR1). Anesthesiology 95:716–725
Robinson EP, Sams RA, Muir WW (1986) Barbiturate anesthesia in greyhound and mixed-breed
dogs: comparative cardiopulmonary effects, anesthetic effects, and recovery rates. Am J Vet
Res 47:2105–2112
Robinson R, Carpenter D, Shaw MA, Halsall J, Hopkins P (2006) Mutations in RYR1 in malignant
hyperthermia and central core disease. Hum Mutat 27:977–989
Roussel F, Duignan DB, Lawton MP, Obach RS, Strick CA, Tweedie DJ (1998) Expression and
characterization of canine cytochrome P450 2D15. Arch Biochem Biophys 357:27–36
Roy-Chowdhury J, Huang TJ, Kesari K, Lederstein M, Arias IM, Roy-Chowdhury N (1991)
Molecular basis for the lack of bilirubin-specific and 3-methylcholanthrene-inducible UDP-
glucuronosyltransferase activities in Gunn-rats. The two isoforms are encoded by distinct
mRNA species that share an identical single base deletion. J Biol Chem 266:18294–18298
Sakai N, Saito K, Sakamoto KQ, Ishizuka M, Fujita S (2009) Genetic basis of inter- and intrastrain
differences in diazepam p-hydroxylation in rats. Drug Metab Dispos 37:268–271
Salavaggione OE, Kidd L, Prondzinski JL, Szumlanski CL, Pankratz VS, Wang L, Trepanier L,
Weinshilboum RM (2002) Canine red blood cell thiopurineS-methyltransferase: companion
animal pharmacogenetics. Pharmacogenetics 12:713–724
Salavaggione OE, Yang C, Kidd LB, Thomae BA, Pankratz VS, Trepanier LA, Weinshilboum RM
(2004) Cat red blood cell thiopurineS-methyltransferase: Companion animal pharmaco-
genetics. J Pharmacol Exp Ther 308:617–626
Sams RA, Muir WW (1988) Effects of phenobarbital on thiopental pharmacokinetics in grey-
hounds. Am J Vet Res 49:245–249
Sams RA, Muir WW, Detra RL, Robinson EP (1985) Comparative pharmacokinetics and anes-
thetic effects of methohexital, pentobarbital, thiamylal, and thiopental in Greyhound dogs and
non-Greyhound, mixed-breed dogs. Am J Vet Res 46:1677–1683
Sartor LL, Bentjen SA, Trepanier L, Mealey KL (2004) Loperamide toxicity in a collie with the
MDR1 mutation associated with ivermectin sensitivity. J Vet Intern Med 18:117–118
Sasaki Y, Ohsako S, Deguchi T (1991) Molecular and genetic analyses of arylamine N-acetyl-
transferase polymorphism of rabbit liver. J Biol Chem 266:13243–13250
Schinkel AH, Smit JJM, Van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, Mol CAAM,
van dr Valk MA, Robanus-Maandag EC, te Riele HPJ, Berns AJM, Borst P (1994) Disruption
of the mousemdr1ap-glycoprotein gene leads to a deficiency in the blood-brain barrier and to
increased sensitivity to drugs. Cell 77:491–502
Comparative and Veterinary Pharmacogenomics 75