David and Goliath: Underdogs, Misfits, and the Art of Battling Giants

(Darren Dugan) #1

This was the world’s authority.”
But Frei and Freireich and a
companion group at the Roswell Park
Memorial Institute in Buffalo led by
James Holland became convinced that
the medical orthodoxy had it backwards.
If the drugs weren’t killing enough
cancer cells, didn’t that mean that the
children needed more aggressive
treatment, not less? Why not combine 6-
MP and methotrexate? They each
attacked cancer cells in different ways.
They were like the army and the navy.
Maybe the cells that survived 6-MP
would be killed by methotrexate. And
what if they added prednisone into the
mix? It could be the air force, bombing

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