752/SWEET WOODRUFFtration. This effect is reversible following discontinuation of
the drug. Liver enzyme values should be monitored.DOSAGE
Mode of Administration: The herb is obsolete as a drug in
many countries, and since 1981 is not allowed to be used in
the manufacture of aroma or flavoring in German-speaking
countries.Preparation: To make a tea, place 2 teaspoonfuls (1.8 gm
drug) in one glass water. An infusion of 5% drug is used for
insomnia, and a forehead poultice made of crushed herb is
used for headache.Daily Dosage: The average single dose is 1.0 gm drug. The
preparations can be taken during the day or shortly before
going to bed.Storage: The drug should be protected from light sources to
avoid brown coloring.LITERATURE
Anonym, Cumarin (1,2-b-Benzopyron) - Neue Erkenntnisse zur
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Bqjthe-Horvath K et al., PH 21:2917-2919. 1982.
Burnett AR, Thomsom RH, (1968) J Clin Soc (6):854.
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Cox D, O'Kennedy R, Thomes RD, The rarity of liver toxicity
in patients treated with coumarine (1,2-Benzopyrone). In:
Human Toxikol 8:501-506. 1989.
Egan D, O'Kennedy R, Moran E, Cox D, Prosser E, Thornes
RD, The pharmacology, metabolism, analysis, and applications
of coumarin and coumarin-related compounds. In: Drug
Metabolism Reviews 22(5):503-529. 1990.
Ellinger A, Zur pharmako-dynamischen Charakterisierung des
Cumarins. In: Schmiedebergs Arch exp Pathol Pharmakol Suppl.
Festschrift, S.150-163. 1908.
Fentem JH, Fry JR, Thomas NW, Species differences in the
hepatotoxicity of coumarin - a comparision of rat and
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Hardt TJ, Ritschel WA, The effect of coumarin and 7-
hydroxycoumarin on in vitro macrophage phagocytosis of latex
particles. In: Methods Find Exp Clin Pharmacol 5(l):39-43.
1983.Hausen BM, Schmieder M, The sensitizing capacity of
coumarins. In: Contact Dermatitis 15(3): 157-163. 1986.
PDR FOR HERBAL MEDICINESHazleton LW, Tusing TW, Zeitlin BR, Thiesen R, Murer HK,
Toxicity of coumarin. In: J Pharmacol Exp Ther 116:348-358.
1956.
Inouye H et al., (1974) Planta Med 25:285.
Kooiman P, Acta Bot Neerl 18:124-137. 1966.
Laub E, Olszowski W, Woller R. Waldmeister und Maibowle.
Pharmazeutisch und lebensmittelchemische Aspekte. In: Dtsch
Apoth Ztg 125:848-850. 1985.
Mascolo N et al., (1987) Phytother Res 1 (1):28.
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1992.
Sporn A, Toxicity of coumarin as a flavoring agent. In: Igenia
(Bucharest^: 121-126. 1960.
Sticher O et al., (1971) Dtsch Apoth Ztg 111:1795.
Wiistenberg, P, Baumann G, Verdacht der Toxizitat von
Cumarin nicht bestatigt. In: PZ 139(13): 1058. 1994.
Further information in:
Frohne D, Pfander HJ: Giftpflanzen - Ein Handbuch fur
Apotheker, Toxikologen und Biologen, 4. Aufl.. Wiss.
.Verlagsges. mbH Stuttgart 1997.
Hansel R, Keller K, Rimpler H, Schneider G (Hrsg.), Hagers
Handbuch der Pharmazeutischen Praxis, 5. Aufl., Bde 4-6
(Drogen), Springer Verlag Berlin. Heidelberg, New York, 1992-
1994.
Leung AY, Encyclopedia of Common Natural Ingredients Used
in Food Drugs and Cosmetics, John Wiley & Sons Inc., New
York 1980.
Madaus G, Lehrbuch der Biologischen Arzneimittel, Bde 1-3,
Nachdruck, Georg Olms Verlag Hildesheim 1979.
Roth L, Daunderer M, Kormann K, Giftpflanzen, Pflanzengifte,- Aufl., Ecomed Fachverlag Landsberg Lech 1993.
Steinegger E, Hansel R, Pharmakognosie, 5. Aufl., Springer
Verlag Heidelberg 1992.
Teuscher E, Lindequist U, Biogene Gifte - Biologie, Chemie,
Pharmakologie, 2. Aufl., Fischer Verlag Stuttgart 1994.
Teuscher E, Biogene Arzneimittel, 5. Aufl., Wiss. Verlagsges.
mbH Stuttgart 1997.
Swertia chirata
See Chiretta
Swertia japonica
See Senburi