PDR for Herbal Medicines

HERBAL MONOGRAPHS ZYZYPHUS JUJUBE/847

ACTIONS AND PHARMACOLOGY

COMPOUNDS

Volatile oil (1.0-1.5%): chief components zingiberene, 1,8-

cineole, D-camphor, D-camphene, D-borneol, alpha-pinene,

also including among others curcumol, zederone, curcume-

neol, curculone, furanodienone, isofuranodienone

Curcuminoids: curcumin, desmethoxycurcumin, bisdes-

methoxycurcumin

Starch (50%)

EFFECTS

Main active principles: essential oil, tannins, mucilage,

small-grained starch. In animal tests, the drug has a

choleretic, mildly antacid and spasmolytic effect, as well as

increasing intestinal transit time. The ethanol extract (main

active principle p-methoxy cinnamic acid ethyl ester) is a

strong fungicide. An anti-tumoral effect has also been

proven.

INDICATIONS AND USAGE

Unproven Uses: Zedoary is used as a stomachic for digestive

debility, colic and spasms (stomachic, carminative). In folk

medicine, it is also used as a remedy for nervous diseases.

Indian Medicine: In India, the drug is used for loss of

appetite, tuberculosis, wounds, leukodermia, fever, bronchi-

tis and asthma.

PRECAUTIONS AND ADVERSE REACTIONS

General: No health hazards or side effects are known in

conjunction with the proper administration of designated

therapeutic dosages.

Pregnancy: Not to be used during pregnancy.

DOSAGE
Mode of Administration: Zeodary is available as solid and
liquid dosage forms for oral intake.

How Supplied: Capsules: 300 mg, 450 mg; liquid: 1:4.

Preparation: Extracts of the drug are contained in numerous

combination preparations for gastrointestinal indications and

as cholagogues. To prepare an infusion, pour boiling water

over 1 to 1.5 gm of comminuted or powdered drug, or put in

cold water and strain after 3 to 5 minutes (1 teaspoonful = 3

gm of drug).

Daily Dosage: Drink 1 cup as an aromatic bitter at meals.

LITERATURE

Gupta SK et al., Lloydia 39:218-222. 1976.

Hansel R, Keller K, Rimpler H. Schneider G (Hrsg.), Hagers

Handbuch der Pharmazeutischen Praxis, 5. Aufl., Bde 4-6

(Drogen): Springer Verlag Berlin. Heidelberg, New York, 1992-

1994.

Hikino H et al., (1970) Chem Pharm Bull 18:752.

Kuronayagi M, Natori S, Yakugaku Zasshi 90:1467-1470. 1970.

Latif MA et al., Br J Nutr 41:57. 1979.

Matthes HWD et al., (1980) Phytochemistry 19:2643.

Shiobara Y et al., (1985) Phytochemistry 24(11):2629.

Zingiber officinale

See Ginger

Zyzyphus jujube

See Jujube