222 /CORIANDER PDR FOR HERBAL MEDICINES
PRECAUTIONS AND ADVERSE REACTIONS
Health risks or side effects following the proper administra-
tion of designated therapeutic dosages are not recorded. The
drug possesses a weak potential for sensitization.
DOSAGE
Mode of Administration: Crushed and powdered drug, as
well as other galenic preparations for internal indication.
Preparations: Coriander extract 1:2 is prepared by percolat-
ing 1 weight part of the drug with 45% ethanol so that 2
weights tincture is produced. The infusion is prepared by
pouring 150 ml of boiling water over 2 tsp. of crushed drug
and straining after 15 minutes.
Daily Dosage: The average daily dose is 3.0 gm of drug. The
single dose is 1 gm.
Infusion — 1 fresh cup between meals.
Tincture — 10 to 20 drops after meals.
Storage: The non-comminuted drug is stored at a maximum
temperature of 25°C, protected from light in well-sealed
containers.
LITERATURE
Calcandi V. Ciropol-Calcandi I. Georgescu E, PA 16(6):331-
- Diedreichsen A et al., Chemotypes of Coriandrum sativum L. in
the Gatersleben Genebank. In: PM 62, Abstracts of the 44th
Ann Congress of GA, 82. 1996.
Formacek. Buch. In: Formacek, V, Kubeczka KH: Essential
Oils Analysis by Capillary Gas Chromatography and Carbon-13-
NMR Spectroscopy, John Wiley & Sons, Chicester, New York,
Brisbane, Toronto. Singapore 1982.
Gijbels MJM et al.. (1982) Fitoterapia 53(1/2):17.
Ram AS, Devi HM, (1983) Indian J Bot 6(1):21.
Schratz E, Quadry SMJS, PM 14(3):310-325. 1966.
Further information in:
Fenaroli's Handbook of Flavor Ingredients, Vol. 1, 2nd Ed.,
CRC Press 1975.
Hansel R, Keller K, Rimpler H, Schneider G (Ed), Hagers
Handbuch der Pharmazeutischen Praxis. 5. Aufl., Bde 4-6
(Drogen), Springer Verlag Berlin, Heidelberg, New York, 1992-
1994
Leung AY, Encyclopedia of Common Natural Ingredients Used
in Food, Drugs and Cosmetics. John Wiley & Sons Inc. New
York 1980.
Mascolo N et al., Phytother Res 1 (1987), 28.
Simon JE, Chadwick AF, Craker LE (Eds.), Herbs. An Indexed
Bibliography 1971-80. Archon Books, USA 1984.
- Diedreichsen A et al., Chemotypes of Coriandrum sativum L. in
Steinegger E, Hansel R, Pharmakognosie, 5. Aufl., Springer
Verlag Heidelberg 1992.
Teuscher E, Biogene Arzneimittel, 5. Aufl., Wiss. Verlagsges.
mbH Stuttgart 1997.
Wichtl M (Hrsg.), Teedrogen, 4. Aufl., Wiss. Verlagsges.
Stuttgart 1997.
Coriandrum sativum
See Coriander
Corn Cockle
Agrostemma githago
DESCRIPTION
Medicinal Parts: The medicinal part of the herb is the seed.
Flower and Fruit: The flowers are apical or arranged in twos
or threes like a curled cyme; the 5 sepals of the calyx have 2
to 4 cm long tips that project above the corolla; the flower
tube is 14 to 18 mm. The 5 petals are 30 to 35 mm long, dark
purple and occasionally whitish. There are 5 styles and 10
stamens. The ovary is superior, undivided and has a central
placenta. The fruit capsule is 15 to 18 mm long with
numerous 2.5 to 3.5 mm long, warty seeds.
Leaves, Stem and Root: Agrostemma githago is an annual
herb that grows upright, up to 100 cm high. The leaves are
opposite, linear-lanceolate, acuminate and up to 10 mm
wide. The stem is upright, usually unbranched, shaggy-gray-
pubescent. The primary root is spindle-shaped and heavily
branched.
Habitat: Europe and Asia
Production: Corn cockle seed is the dried seed of Agrostem-
ma githago.
Other Names: Cockle
ACTIONS AND PHARMACOLOGY
COMPOUNDS
Triterpene saponins: chief component is githagoside (0.04%,
gypsogenine tetraglycoside), additional components are gyp-
sogenin and quillaic acid gylcosides
Fatty oil: 6%
Steroids: sterols, including alpha-spinasterol
Unusual amino acids: orcyl alanine (0.4%)
EFFECTS
The drug exhibits an antimycotic effect. Cornflower seeds
are toxic in higher dosages.