PDR for Herbal Medicines

(Barré) #1
502/MARIJUANA PDR FOR HERBAL MEDICINES

Appetite stimulation — (Marinol®) 2.5 mg to 10 mg twice
daily

Antiemetic
times daily

(Marinol®) 5 mg/m^2 to 15 mg/m^2 four to six

Narcotic — hash .and tobacco are mixed. 1 cigarette contains
0.5 gm to 1 gm of the drug with at least 5 mg to 10 mg d-9-
tetrahydrocannabinol for the psychotropic effect. More exact
dosages are almost impossible to stipulate due to the
varieties of action of the different cannaboids and because of
varying breathing techniques.
Storage: Store with care, protected from light. Studies have
shown that 9-tetrahydrocannabinol has a strong affinity with
synthetics and rubber and is easily absorbed by them.
LITERATURE
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Mechoulam R, Vogel Z Cannabis sativa - deceptive weed? S
Afr Med J, 271:1269-70, 1995 Dec
Bonnin A et al Effects of perinatal exposure to delta 9-
tetrahydrocannabinol on the fetal and early postnatal
development of tyrosine hydroxylase-containing neurons in rat
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Evans FJ, Cannabinoids - The separation of central from
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Fairbairn JW et al., J Pharm Pharmacol 28:130.
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Gil EW et al., (1970) Nature 228:135.
Goedecke H, Karkos J, Die arzneiliche Verwendung von
Cannabisprodukten. In: DAZ 136(34):2859-2862. 1996.
Jungmayr P, Rauschmittel: Macht Marihuana dumm? In: DAZ
136(34):2867-2868. 1996.
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1992.

Nahas, B, In: Marihuana in Science and Medicine. Nahas G
(Ed.) Raven Press New York. 1984.


Paris RR et al., (1976) Plant Med Phytother 10:144.


Ross SA, ElSohly MA, The volatile oil composition of fresh
and air-dried buds of Cannabis. In: JNP 59(1):49-51. 1996.
Ruh MF, Taylor JA, Howlett AC, Welshons WV Failure of
cannabinoid compounds to stimulate estrogen receptors.
Biochem Pharmacol, 53:35-41, 1997 Jan 10
Ruh MF, Taylor JA, Howlett AC, Welshons WV The volatile
oil composition of fresh and air-dried buds of Cannabis sativa.
J Nat Prod, 53:49-51, 1996 Jan
Segelman A et al., (1977) J Pharm Sci 66:1358.
Taschner KL, Drogen und Stra|3enverkehr. In: DAZ
134(35):3299. 1994.
Taura F, Morimoto S, Shoyama Y Three acyclic bis-
phenylpropane lignanamides from fruits of Cannabis sativa.
Phytochemistry, 271:1003-7, 1995 Mar
Turner CE et a!., (1980) J Nat Prod 43:169.
Vidal C, Fuente R, Iglesias A, Saez A Bronchial asthma due to
Cannabis sativa seed. Allergy, 40:647-9, 1991 Nov
Yamamoto I, Matsunaga T, Kobayashi H, Watanabe K,
Yoshimura H Analysis and pharmacotoxicity of feruloyltyramine
as a new constituent and p-coumaroyltyramine in Cannabis
sativa L. Pharmacol Biochem Behav, 40:465-9, 1991 Nov
Yamaudi T, (1975) Phytochemistry 14:2189.
Further information in:
Barrett ML et al Biochem Pharmacol 34 (1985), 2019
Burstein S, Ozman K Biochem Pharmacol 34 (1982), 2019
Frohne D, Pfander HJ, Giftpflanzen - Ein Handbuch fur
Apotheker, Toxikologen und Biologen, 4. Aufl., Wiss. Verlags-
Ges. Stuttgart 1997.
Gruenwald J, Brendler T, Jaenicke C (Eds) Physicians Desk
Reference for Herbal Medicines. Medical Economics Company
Inc., Montvale, 1998
Hansel R, Keller K, Rimpler H, Schneider G (Hrsg.), Hagers
Handbuch der Pharmazeutischen Praxis, 5. Aufl., Bde 4-6
(Drogen), Springer Verlag Berlin, Heidelberg, New York, 1992-
1994.
Hernandez ML, Garcia-Gil L, Berrendero F, Ramos JA,
Fernandez-Ruiz JJ delta 9-Tetrahydrocannabinol increases
activity of tyrosine hydroxylase in cultured fetal mesencephalic
neurons. J Mol Neurosci, 8:83-91, 1997 Apr
Lercker G, Bocci F, Frega N, Bortolomeazzi R Cannabinoid
acids analysis. Farmaco, 40:367-78, 1992 Mar
Lewin L, Gifte und Vergiftungen, 6. Aufl., Nachdruck, Haug
Verlag, Heidelberg 1992.
Mackie K, Hille B Cannabinoids inhibit N-type calcium
channels in neuroblastoma-glioma cells. Proc Natl Acad Sci U
S A, 89:3825-9, 1992 May 1
Mackie K, Hille B Passive consumption of marijuana through
milk: a low level chronic exposure to delta-9-
tetrahydrocannabinol(THC). J Toxicol Clin Toxicol, 89:255-60,
1990
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