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COCILLANA BARK
Source: Guarea rusbyi(Britt.) Rusby (syn.
Sycocarpus rusbyiBritt.) and closely relat-
ed species (Family Meliaceae).
Common/vernacular names:Cocillana bark,
grape bark, guapi, trompillo, and upas.
GENERAL DESCRIPTION
Trees native to the South American Andes.
Part used is the dried bark. The original co-
cillana bark is believed to be derived from
G. rusbyi. However, there is evidence that the
current drug is obtained from other closely
relatedGuareaspecies and is not the same as
the cocillana first introduced into modern
medicine (USD23rd).^1 The bark is collected
in Haiti and Bolivia (EVANS).
CHEMICAL COMPOSITION
Chemical studies on cocillana are limited.
Cocillana bark is reported to contain small
amounts (0.003–0.023%) of alkaloid(s) (rus-
byine) of which the chemical structure(s) has
not been determined. It also containsb-sitos-
terol, a volatile oil, tannin, anthraquinones,
flavonols, terpenoids, and others (LIST AND
HO ̈RHAMMER).^1
PHARMACOLOGY AND BIOLOGICAL
ACTIVITIES
Cocillana is reported to have expectorant and,
in higher doses (1.3–3.0 g), emetic properties
similar to those of ipecac (BRADLY;LIST AND
HO ̈RHAMMER).^1 These properties are based on
findings reported at the end of the last century.
No recent pharmacological or toxicological
data on cocillana are available.
Cocillana bark 215
