- S. Fulder,New Sci., 1 , 138 (1977).
- Y. K. Gupta et al.,Indian J. Physiol.
Pharmacol., 45 , 502 (2001). - J. C. Yang et al.,Am. J. Chin. Med., 29 ,
149 (2001). - J. Moon et al.,Biochem. Pharmacol., 59 ,
1109 (2000). - J. Sohn et al.,Exp. Mol. Med., 30 ,47
(1998). - I. A. Persson et al.,J. Ethnopharmacol.,
105 , 321 (2006). - M. F. Caron et al.,Ann. Pharmacother.,
36 , 758 (2002). - J. H. Lee et al.,Planta Med., 70 , 615
(2004). - N. I. Belogortseva et al.,Planta Med.,
66 , 217 (2000). - C. S. Jeong et al.,Arch. Pharm. Res., 26 ,
906 (2003). - S. O. Shibata et al., in H. Wagner, H.
Hikino, and N. R. Farnsworth, eds.,
Economic and Medicinal Plant
Research, Vol. 1, Academic Press,
Orlando, FL, 1985, p. 218. - T. B. Ng and H. W. Yeung,in R. P.
Steiner, ed.,Folk Medicine, The Art
and the Science, American Chemical
Society, Washington, DC, 1986, p. 139.
- J. A. Duke, Ginseng—A Concise
Handbook, Reference Publications,
Algonac, MI, 1989. - H. Saito in Proceedings of the 3rd
International Ginseng Symposium,
Korean Ginseng Research Institute,
Seoul, Korea, 1980, p. 181. - W. H. Lewis in N. L. Etkin, ed.,Plants in
Indigenous Medicine and Diet:
Biobehavioral Approaches, Red grave
Publishing Co., Bedford Hills, NY,
1986, p. 290. - Y. Dai et al.,Zhongguo Yaoli Xuebao, 9 ,
562 (1988). - Y. S. Chang et al.,Planta Med., 52 , 338
(1986). - S. Helms, Altern. Med. Rev., 9 , 259
(2004). - V. A. Assinewe et al.,J. Agric. Food
Chem., 51 ,4549 (2003). - Y. S. Chang et al.,Integr. Cancer Ther.,
2 , 13 (2003). - J. T. Coon and E. Ernst,Drug Saf., 25 ,
323 (2002).
GOLDENSEAL
Source: Hydrastis canadensis L. (Family
Ranunculaceae).
Common/vernacular names: Orange root,
yellow root, jaundice root, Indian turmeric,
eye root, and eye balm.
GENERAL DESCRIPTION
A perennial herb with a knotty yellow rhizome
(rootstock) from which arise a single leaf (rad-
icalleaf)andanerecthairysteminearlyspring
bearing two five- to nine-lobed rounded leaves
near the top, terminated by a single greenish
white flower; up to about 30 cm high; native to
rich, moist, deciduous forests, Vermont to
Georgia, west to Alabama and Arkansas, north
to eastern Iowa and Minnesota; formerly
cultivated in Oregon and Washington. Various
botanical writers note rarity where it once
flourished due to overcollection of the root.^1
Parts used are the dried rhizome and roots.
CHEMICAL COMPOSITION
Contains as active principles isoquinoline
alkaloids consisting mainly of hydrastine
(1.5–4%) and berberine (0.5–6%), with lesser
336 Goldenseal