0071483446.pdf

CHAPTER 13 Antimicrobials—Fighting Infection^231

Aminoglycosides

Pregnancy Category: C

Route Dose Time

Amikacin (Amikin)

Protein-Binding: 4%–11%

Half-Life: 2–3 hours

IM/IV 5 mg/kg Every 8 hours

Gentamicin (Garamycin)

Protein-Binding: Unknown

Half-Life: 2 hours

IM/IV 1–1.7 mg/kg Infusion every 8 hours

Kanamycin (Kantrex)

Protein-Binding: 10%

Half-Life: 2–3 hours

Pregnancy Category: D

IM 3.75 mg/kg Every 6 hours

Neomycin SO 4 (Myclfradin)

Protein-Binding: 10%

Half-Life: 2–3 hours

PO (GI Surgery) 1 g Every hour for 4 doses

1 g Every 4 hours there-

after for 24 hours or

other regimens

(Hepatic Coma) 4–12 g/d Divided doses

IM 15mg/kg/d Every 6 h for 4 doses

Max 1 g/d

Netilmicin (Netromycin)

Protein-Binding: 10%

Half-Life: 2–3 hours

Pregnancy Category: D

IM/IV 1.3–2.2 mg/kg Every 8 hours