Anticholinergic
Insomnia/
Category
effect
Sedation
Hypotension
GI distress
Cardiotoxicity
Seizures
Agitation
Tricyclic AntidepressantsAmitriptyline (Elavil)
++++
++++
+++
++++
+++
Clomipramine (Anafranil)
++++
++++
++
++++
++
Despramine (Norpramin)
+
++
++
++
++
+
Doxepin (Sinequan)
+++
++++
++
++
++
Imipramine (Tofranil)
+++
+++
+++
+
++++
++
+
Nortriptyline (Aventyl)
+
+++
+
+++
++
Protriptyline (Vivactil)
+++
+
++
+++
+
+
Trimipramine (Surmontil)
+++
++++
+++
++++
++
Selective Serotonin Reuptake InhibitorsFluoxetine (Prozac)
+
+++
0/+
++
Fluvoxamine (Luvox)
++
+++
++
Paroxetine (Paxil)
+
+++
++
Sertraline (Zoloft)
+
+++
++
Table 15-3.
Side effects of antidepressants.
299