CHAPTER 36 • PULMONARY 211
osteoarthritis and rheumatoid arthritis: Systematic review of
randomized controlled trials. BMJ325, 21 Sep 2002.
Fogoros R: Runner’s trots. JAMA243, 1980.
Hirschowitz BI: A critical analysis, with appropriate controls of
gastric acid and pepsin secretion in clinical esophagitis.
Gastroenterol101, 1991.
Kahrilas PJ, Fenerty MB, Joelsson B: High-versus standard-dose
ranitidine for control of heartburn in poorly responsive acid
reflux disease: A prospective, controlled trial. Am J Gastro-
enterol 94, 1999.
Keefe EB et al: Gastrointestinal symptoms of marathon runners.
West J Med41, 1984.
Lauder TD, Moses FM: Recurrent abdominal pain from abdomi-
nal adhesions in an endurance triathlete. Med Sci Sports Exerc
27(5), 1995.
Lichtenstein DR, Syngal S, Wofe MM: Nonsteroidal anti-inflam-
matory drugs and the gastrointestinal tract. Arthritis Rheum
38(5), 1995.
Lijnen P et al: Indicators of cell breakdown in plasma in men
during and after a marathon race. Int J Sports Med9(2),
1988.
Liver enzyme elevation referral guideline. http://www.mamc.amedd.
army.mil/referral/guidelines, 30 September 1999.
Malfertheiner P et al: Current concepts in the management of
Helicobacter pylori infection—the Maastrict 2-2000 consen-
sus report. Aliment Pharmacol Ther16(2), 2002.
McCabe, ME 3d, et al: Gastrointestinal blood loss associated
with running a marathon. Dig Dis Sci31, 1986.
Nilius M, Malfertheiner P: Helicobacter pylori enzymes. Aliment
Pharmacol Ther 10 (Suppl 1), 1996.
Pate R: Principles of training, in Kulund D (ed.): The injured ath-
lete. Philadelphia, PA, JB Lippincott, 1988.
Peters HP et al: Gastrointestinal symptoms in long-distance run-
ners, cyclists, and triathletes: Prevalence, medication, and eti-
ology. Am J Gastroenterol94(6), 1999a.
Peters HP et al: Gastrointestinal symptoms during long-distance
walking. Med Sci Sports Exerc31, 1999b.
Rehrer N et al: Fluid intake and gastrointestinal problems in run-
ners competing in a 25-km marathon. Int J Sports Med10,
1989.
Richter JE:. Typical and atypical presentations of gastroe-
sophageal reflux disease. Gastroenterol Clin25(1), 1996.
Soffer EE et al: Effect of graded exercise on esophageal motility
and gastroesophageal reflux in trained athletes. Dig Dis Sci38,
1993.
Spechler JS: Peptic ulcer disease and its complications, in
Feldman M, Friedman LS, Sleisinger MH (eds.): Sleisenger
and Fordtran’s Gastrointestinal and Liver Disease, 7th ed.
Philadelphia, PA, Saunders, 2002.
Stamford B: A “stitch’’ in the side. Phys Sportsmed13, 1985.
Tytgat G et al: Campylobacter-like organism (CLO) in the human
stomach. Gastroenterology88, 1985.
Williams MP et al: A placebo-controlled trial to assess the
effects of 8 days of dosing with rabeprazole versus omepra-
zole on 24-hourintragastric acidity and plasma gastrin concen-
trations in young healthy male subjects. Aliment Pharmocol
Ther12, 1998.
Wysowski KD, Bacsanyi J: Cisapride and fatal arrhythmia.
[letter] N Engl J Med335, 1996.
36 PULMONARY
Carrie A Jaworski, MD
INTRODUCTION
•Patients with pulmonary disorders can benefit greatly
from exercise when their disease process is under
proper control.
•Awareness of when and when not to participate as
well as the ability to use pharmacologic agents and
environmental controls greatly enhances one’s ability
to participate safely.
ASTHMA
- Asthma is a pulmonary disorder characterized by
chronic inflammation of the airways leading to
bronchial hyperreactivity. While in the past, asthmat-
ics were discouraged from exercise, today it is recog-
nized that regular exercise can reduce airway
reactivity and decrease medication use (Disabella and
Sherman, 1998). - Approximately 17 million adults and 5 million chil-
dren in the United States have chronic asthma (NIH,
1997). - The National Heart, Lung, and Blood Institute
(NHLBI) has set forth guidelines on the diagnosis and
management of asthma in an effort known as the
National Asthma Education and Prevention Program
(NAEPP). This program is evidence-based and rou-
tinely updates its recommendations based on the
newest research. See NHLBI website for most recent
recommendations @www.NHLBI.org.
DIAGNOSIS OF ASTHMA
- History or presence of episodic symptoms of airflow
obstruction such as wheezing, chest tightness, short-
ness of breath, or cough. Absence of symptoms at
time of examination does not exclude diagnosis. - Airflow obstruction needs to be at least partially
reversible demonstrated through the use of spirometry.
First establish airflow obstruction: FEV 1 <80% pre-
dicted and FEV 1 /FVC <65% or below the lower limit
of normal. Then establish reversibility by an FEV 1
increase of ≥12% and at least 200 mL after using a
short-acting inhaled beta2-agonist. (FEV 1 =Forced
expiratory volume in 1 s; FVC =Forced vital capacity)
(NIH, 1997).