Science - USA (2022-02-25)

CREDITS: (PHOTO TAPANI KARJANLAHTI/TVO; (ILLUSTRATION HANNAH AGOSTA

INSIGHTS

BOOKS E T A L.

812 Science at Sundance 2022

PERSPECTIVES

816 Losing sleep with age

Hypocretin neuron hyperexcitability

underlies disrupted sleep quality associated

with age By L. H. Jacobson and D. Hoyer

RESEARCH ARTICLE p. 838

SCIENCE science.org 25 FEBRUARY 2022 • VOL 375 ISSUE 6583 795

NEWS

IN BRIEF

798 News at a glance

IN DEPTH

801 United Nations to tackle global

plastics pollution

Research could gain from negotiations to

reduce, reuse, and recycle the common

material By E. Stokstad

802 Biden gets pans and praise for

dividing top science positions

Francis Collins named as science

adviser and Alondra Nelson as

head of White House science office

By J. Mervis

803 Oldest genomes from Africa

offer glimpse of complex past

Signs of ice age isolation match

archaeological clues By M. Price

804 Glowing tumor marker hampers

mouse cancer studies

Response to protein complicates

immunotherapy research By J. Kaiser

805 Novel viruses highlight risks

of Asia’s wild animal trade

Sampling of game in China reveals

many viral threats By J. Cohen

817 Inferring human evolutionary history

Unified genetic genealogy improves our

understanding of how humans evolved

By J. Rees and A. Andrés

RESEARCH ARTICLE p. 836

818 Anticipating antibiotic resistance

Machine learning can use clinical history

to lower the risk of infection recurrence

By J.-B. Lugagne and M. J. Dunlop

REPORT p. 889

820 Dimerization decrypts

antibiotic activity

Direct dimerization simplifies the

synthesis of himastatin

and elucidates its mode of action

By M. Smith

REPORT p. 894

821 A crooked spinning black hole

New observations challenge the

current understanding of black hole

formation By F. Patat and M. Mapelli

REPORT p. 874

822 Flashing light with nanophotonics

Manipulation and enhancement of

scintillation is achieved in nanophotonic

structures By R. Yu and S. Fan

RESEARCH ARTICLE p. 837

824 C. Thomas Caskey

(1938–2022)

A visionary architect of genomic

medicine By A. Ballabio and H. Zoghbi

CONTENTS

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25 FEBRUARY 2022 • VOLUME 375 • ISSUE 6583

812

FEATURES

806 Final resting place

Finland is set to open the world’s first

permanent repository for high-level nuclear

waste. How did it succeed when other

countries stumbled? By S. El-Showk

PODCAST