Biology of Disease

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X]VeiZg,/ DISORDERS OF THE ENDOCRINE SYSTEM


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Figure 7.11 Overview of the causes of endocrine
disorders.

Figure 7.12 Structure of the pituitary gland, with
the secreted hormones indicated.

Stimulus

Endocrine
gland

Hormone
synthesis

Storage

Release

Hormone

e.g. lung
tumor

Ectopic source

Target cell

Inactivation site

Excretory site

e.g. liver

e.g. kidney

Antibodies
against gland

Biochemical and
physiological effects

Abnormal
stimulus

Defective
synthesis

Defective
interactions with
target cells

Inappropriate
feedback
control

Defective inactivation
and/or excretion

Defective
release

SSSSSS
SS
SSSS

Oxytocin
ADH

Posterior
pituitary gland

Anterior
pituitary gland

Artery

TSH
ACTH
FSH
LH
Prolactin
GH

Stalk
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