Quick Review Cards for Medical Laboratory Science

Transfusion-Associated Infections Immunohematology Review 471

INFECTION PREVENTION COMMENTS

HIV

Hepatitis B

Hepatitis C

HTLV-I and -II

Syphilis

Malaria

Babesiosis

Chagas’ disease

Cytomegalovirus

Estimated risk: 1 in 1,467,000 transfusions. With NAT, window period 9 days.

Estimated risk: 1 in 280,000 transfusions.

Estimated risk: 1 in 1,149,000 transfusions. With NAT, window period 7.4 days.

Rare in U.S.

Limited risk in refrigerated or frozen components. Spiro- chetes can’t survive in cold. Highest risk from platelets.

Plasmodiumis transmitted in RBCs.

Babesiais transmitted in RBCs.

Trypanosoma cruziis transmitted in blood. Potential risk in donors from Central & S. America.

CMV transmitted in WBCs. Risk to CMV-neg immunocom- promised pts & premature infants of CMV-neg mothers.

Donor testing

Donor history

Selected donor testing (not routine). Use of CMV-neg or leukoreduced components for pts at risk.

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