Delayed Transfusion Reactions* Immunohematology Review 476
TYPE CLINICAL SIGNS CAUSE LABORATORY FINDINGS OTHER
Immunologic
Hemolytic, extravascular
Alloimmunization
Transfusion-associated
graft-vs.-host disease
(TA-GVHD)
May be due to anamnestic
response. Kidd antibodies
most common cause. Usually
not life-threatening.
Use leukoreduced components
for pts with WBC abs.
Irradiate components for pre-
mature infants, intrauterine
or exchange transfusion,
stem cell or bone marrow
transplants, recipients of
blood from a 1st-degree
relative, immunocompro-
mised, pts with leukemia
or lymphoma.
Donor RBCs sensitized
by recipient IgG ab
& removed from
circulation.
Development of abs to
foreign RBCs, WBCs,
platelets, plasma pro-
teins following tf.
Viable T lymphs in
donor blood attack
recipient.
Fever, anemia, mild
jaundice 2–14 days
after tf.
None, unless subse-
quently exposed to
same foreign ags.
Rash, nausea, vomit-
ing, diarrhea, fever,
pancytopenia.
Usually fatal.
↑bili, mixed-field DAT,
↓haptoglobin, ↓HGB
& HCT, pos ab screen
Ab to RBCs detected in
ab screen. Others require
specialized testing.
None
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