MDEA 253
doses are unlikely among healthy users, the same dose can have stronger
effects on some users than on others.
In rat experiments comparing the strength of MDMA to MDEA, about twice
as much MDEA is needed to induce excessive body temperature and about
four times as much to cause one kind of organic brain damage. The experi-
menters note, however, that these findings do not extrapolate well to humans
because people might take greater doses of MDEA than MDMA to get the
desired psychological effects, so any net difference in harm to abusers may be
nil despite difference in drug potency.
Abuse factors.Not enough scientific information to report about tolerance,
dependence, withdrawal, or addiction.
Drug interactions.Medical investigators suspect thatheroinand MDEA
counteract each other’s effects in humans.
Cancer.Not enough scientific information to report.
Pregnancy.Not enough scientific information to report.
Additional scientific information may be found in:
Gouzoulis, E., et al. “Neuroendocrine and Cardiovascular Effects of MDE in Healthy
Volunteers.”Neuropsychopharmacology8 (1993): 187–93.
Gouzoulis-Mayfrank, E., et al. “Psychopathological, Neuroendocrine and Autonomic
Effects of 3,4-Methylenedioxyethylamphetamine (MDE), Psilocybin and D-
Methamphetamine in Healthy Volunteers. Results of an Experimental Double-
Blind Placebo-Controlled Study.”Psychopharmacology142 (1999): 41–50.
Hegadoren, K.M., G.B. Baker, and M. Bourin. “3,4-Methylenedioxy Analogues of Am-
phetamine: Defining the Risks to Humans.”Neuroscience and Biobehavioral Re-
views23 (1999): 539–53.
Hermle, L., et al. “Psychological Effects of MDE in Normal Subjects. Are Entacto-
gens a New Class of Psychoactive Agents?”Neuropsychopharmacology8 (1993):
171–76.